Cleary P E, Ryan S J
Br J Ophthalmol. 1979 May;63(5):312-21. doi: 10.1136/bjo.63.5.312.
The histological findings of the wound, the vitreous, and the retina in the rabbit eye with experimental posterior penetrating injury are described. Wound healing had just begun at 3 days after injury and was well established by 9 to 12 days. It involved proliferation of cells from the episclera and from the choroid. The progression to a fibrous ingrowth from the wound occurred only in eyes with blood in the vitreous. The intravitreal fibroblastic proliferation had begen at 6 days after injury and seemed to be derived from the choroid, the nonpigmented ciliary epithelium and, posteriorly, from the optic nervehead. During the development of retinal detachment the configuration of the peripheral and posterior retina, together with the orientation of vitreous strands, suggested the presence of vitreous traction. We postulate that the presence of contractile fibroblasts (myofibroblasts) in the vitreous may provide the mechanism for vitreous traction. The retinal detachments were also characterised by epiretinal and subretinal membranes, but these were not prominent. The end-stage appearance of a soft, shrunken eye with cyclitic membrane formation and retinal detachment resembles the outcome in many human eyes after severe penetrating injuries.
描述了兔眼实验性后巩膜穿通伤伤口、玻璃体和视网膜的组织学发现。损伤后3天伤口愈合刚刚开始，9至12天时愈合良好。它涉及巩膜外层和脉络膜细胞的增殖。只有玻璃体中有血液的眼睛才会出现伤口处纤维组织向内生长的情况。玻璃体内成纤维细胞增殖在损伤后6天开始，似乎来源于脉络膜、无色素睫状体上皮，以及后部的视神经乳头。在视网膜脱离发展过程中，周边和后部视网膜的形态以及玻璃体条索的方向提示存在玻璃体牵拉。我们推测玻璃体内收缩性成纤维细胞（肌成纤维细胞）的存在可能为玻璃体牵拉提供了机制。视网膜脱离的特征还包括视网膜前膜和视网膜下膜，但这些并不明显。眼睛变软、萎缩，伴有睫状体膜形成和视网膜脱离的终末期表现类似于许多人眼严重穿通伤后的结局。
