酮替芬对哮喘患者甲基转移酶活性的影响。
Effect of ketotifen on the methyltransferase activity of asthmatic patients.
作者信息
Castillo J G, Gamboa P M, Santos F, Oehling A
机构信息
Department of Allergology and Clinical Immunology, Faculty of Medicine, University of Navarra, Pamplona, Spain.
出版信息
Allergol Immunopathol (Madr). 1990 Sep-Oct;18(5):255-9.
The results of this study have revealed that asthmatic individuals have less methyltransferase activity, compared to healthy individuals. This is reflected in a less fluidity of the plasmatic membrane and thus, presents with less beta-receptors compared to healthy subjects. Ketotifen is capable of partially reversing this situation where it stimulates methyltransferase activity of asthmatic individuals approaching the enzyme activity to healthy individuals.
这项研究结果显示，与健康个体相比，哮喘患者的甲基转移酶活性较低。这表现为质膜流动性较低，因此与健康受试者相比，β受体数量较少。酮替芬能够部分扭转这种情况，它可刺激哮喘患者的甲基转移酶活性，使其接近健康个体的酶活性。
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