Spirydovich Siarhei, Papiez Lech, Langer Mark, Sandison George, Thai Van
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
Radiother Oncol. 2006 Dec;81(3):309-14. doi: 10.1016/j.radonc.2006.10.010. Epub 2006 Nov 20.
During radiotherapy planning high density dental materials create a major challenge in determining correct dose distribution inside patients with head-and-neck tumors.
In this work we investigated the absorbed dose distribution inside a solid water slab phantom with embedded high density material irradiated by a 6MV photon beam of field size 10x10cm. We evaluated the absorbed dose distribution with three different techniques: superposition algorithm, radiochromic film, and the fluence map Monte Carlo (FMMC) method.
The results obtained with radiochromic film and FMMC were in good agreement (within +/-5% of the dose) with one another. The superposition algorithm, which is often considered superior to other commercially available dose calculation algorithms, produced appreciably less accurate results than FMMC. In particular, downstream from the high density cerrobend inhomogeneity the superposition algorithm predicts a higher dose than the measurement does by at least 10-16% depending upon the size of the inhomogeneity and the distance from it. Upstream of the high density inhomogeneities the superposition algorithm predicts a lower than measured dose due to its failure to predict the dose enhancement close to the inhomogeneity interface.
The delivered dose downstream from a high density inhomogeneity would be significantly less than the prescribed dose calculated by the superposition algorithm. The FMMC method which is based on a hybrid of the superposition algorithm input fluence data and Monte Carlo can be a useful tool in predicting dose in the presence of high density (e.g. dental) materials.
在放射治疗计划制定过程中,高密度牙科材料给确定头颈部肿瘤患者体内的正确剂量分布带来了重大挑战。
在本研究中,我们调查了一个嵌入高密度材料的固体水模体在10×10cm射野大小的6MV光子束照射下的吸收剂量分布。我们用三种不同技术评估吸收剂量分布:叠加算法、放射变色胶片和注量图蒙特卡罗(FMMC)方法。
放射变色胶片和FMMC获得的结果彼此吻合良好(剂量在±5%以内)。叠加算法通常被认为优于其他商用剂量计算算法,但与FMMC相比,其结果的准确性明显较低。特别是,在高密度铈铋不均匀性的下游,叠加算法预测的剂量比测量值至少高10% - 16%,这取决于不均匀性的大小及其距离。在高密度不均匀性的上游,叠加算法预测的剂量低于测量值,因为它无法预测靠近不均匀性界面处的剂量增强。
高密度不均匀性下游的实际 delivered 剂量将显著低于叠加算法计算的处方剂量。基于叠加算法输入注量数据和蒙特卡罗混合的FMMC方法,在存在高密度(如牙科)材料的情况下预测剂量时可能是一个有用的工具。