Ward Bonnie, McGuinness Lindsay, Akerman Colin J, Fine Alan, Bliss Tim V P, Emptage Nigel J
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Neuron. 2006 Nov 22;52(4):649-61. doi: 10.1016/j.neuron.2006.10.007.
The expression mechanism of long-term potentiation (LTP) remains controversial. Here we combine electrophysiology and Ca(2+) imaging to examine the role of silent synapses in LTP expression. Induction of LTP fails to change p(r) at these synapses but instead mediates an unmasking process that is sensitive to the inhibition of postsynaptic membrane fusion. Once unmasked, however, further potentiation of formerly silent synapses leads to an increase in p(r). The state of the synapse thus determines how LTP is expressed.
长期增强（LTP）的表达机制仍存在争议。在此，我们结合电生理学和Ca(2+)成像技术来研究沉默突触在LTP表达中的作用。LTP的诱导未能改变这些突触处的p(r)，而是介导了一个对突触后膜融合抑制敏感的去掩盖过程。然而，一旦去掩盖，先前沉默突触的进一步增强会导致p(r)增加。因此，突触的状态决定了LTP的表达方式。
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