在委内瑞拉，人类感染犬埃立克体并伴有临床症状。

Human infection with Ehrlichia canis accompanied by clinical signs in Venezuela.

作者信息

Perez Miriam, Bodor Mairim, Zhang Chunbin, Xiong Qingming, Rikihisa Yasuko

机构信息

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210-1093, USA.

出版信息

Ann N Y Acad Sci. 2006 Oct;1078:110-7. doi: 10.1196/annals.1374.016.

DOI:10.1196/annals.1374.016

PMID:17114689

Abstract

A total of 20 human patients with clinical signs compatible with human monocytic ehrlichiosis (HME), who were admitted to the emergency clinic in Lara State, Venezuela, were studied. Thirty percent (6/20) patients were positive for Ehrlichia canis 16S rRNA on gene-specific polymerase chain reaction (PCR). Compared with the U.S. strains, 16S rRNA gene sequences from all six patients had the same base mutation as the sequence of the E. canis Venezuelan human Ehrlichia (VHE) strain previously isolated from an asymptomatic human. This study is the first report of E. canis infection of human patients with clinical signs of HME.

摘要

对委内瑞拉拉腊州急诊诊所收治的20例具有与人类单核细胞埃立克体病（HME）相符临床症状的人类患者进行了研究。在基因特异性聚合酶链反应（PCR）中，30%（6/20）的患者犬埃立克体16S rRNA呈阳性。与美国菌株相比，所有6例患者的16S rRNA基因序列与先前从一名无症状人类分离出的犬埃立克体委内瑞拉人类埃立克体（VHE）菌株序列具有相同的碱基突变。本研究是关于具有HME临床症状的人类患者感染犬埃立克体的首次报告。