Konstantinidis Harilaos D, Slavakis Aristedis P, Ballas Konstantinos D, Sioga Antonia C, Economou Louise D, Demertzidis Charalampos I, Pissanidou Theano T, Athanasiadou Zoi S, Sakadamis Athanasios K
2nd Propedeutical Department of Surgery, Aristotelian University, D. Karaoli 68, Kalamaria, Thessaloniki, TK 55131, Greece.
Dis Colon Rectum. 2007 Jan;50(1):89-96. doi: 10.1007/s10350-006-0727-7.
Capecitabine is a fluoropyrimidine carbamate with antineoplasmatic activity, recommended for the treatment of colorectal cancer. This study was designed to assess the effectiveness of the perioperative administration of capecitabine on the healing process of colonic anastomosis.
Sixty Wistar rats were used, which were randomized in 2 groups of 30 each. The study group was subjected to colonic anastomosis and treated with therapeutic doses of capecitabine (359 mg/kg, or 2/3 of the mean toxic dose) by mouth one week before anastomosis and throughout the study. The control group received only placebo medication. Both groups were further divided into three subgroups, each of ten animals. In both study and control groups, ten animals were killed in each session on postoperative Days 3, 7, and 14.
We found no negative impact on the healing of colonic anastomosis on capecitabine administration. The rate of anastomotic leakage and septic complications were not found to be significantly different between the study and control groups. The median bursting pressure was found to be significantly higher in the study subgroup killed on the third day (68 vs. 46 mmHg of the control group).
Perioperative administration of capecitabine does not have a negative impact on colonic anastomosis in rats.
卡培他滨是一种具有抗肿瘤活性的氟嘧啶氨基甲酸酯，推荐用于治疗结直肠癌。本研究旨在评估围手术期给予卡培他滨对结肠吻合口愈合过程的有效性。
使用60只Wistar大鼠，随机分为2组，每组30只。研究组进行结肠吻合，并在吻合前一周及整个研究期间口服治疗剂量的卡培他滨（359 mg/kg，或平均中毒剂量的2/3）。对照组仅接受安慰剂药物治疗。两组均进一步分为三个亚组，每组十只动物。在研究组和对照组中，分别在术后第3天、第7天和第14天每次处死十只动物。
我们发现给予卡培他滨对结肠吻合口愈合没有负面影响。研究组和对照组之间的吻合口漏率和感染并发症未发现有显著差异。在术后第三天处死的研究亚组中，发现中位破裂压力显著更高（对照组为46 mmHg，研究组为68 mmHg）。
围手术期给予卡培他滨对大鼠结肠吻合口没有负面影响。
