Lim Jennifer C, Wojcik Eva M
Department of Pathology, New York University, New York, NY, USA.
Diagn Cytopathol. 2006 Dec;34(12):797-800. doi: 10.1002/dc.20546.
Papillary renal cell carcinoma is a rare type of renal malignancy. Cytogenetic findings characteristic for this tumor have been described as well as mutations of the proto-oncogene c-met. Secondary malignancies occurring together with papillary renal cell carcinomas are rare, and are often of genitourinary tract origin. We describe two cases of papillary renal cell carcinoma occurring in association with two other visceral malignancies, gastrointestinal stromal tumor and colon adenocarcinoma.Two cases of papillary renal cell carcinoma diagnosed by fine-needle aspiration (FNA), occurring in association with gastrointestinal malignancies were reviewed. Both aspirates showed cytologic features characteristic for papillary renal cell carcinoma, namely papillary structures, foamy histiocytes, intracytoplasmic hemosiderin, and nuclear grooves. Subsequent histology and immunohistochemical stains supported the cytologic diagnosis. The histologic diagnosis of gastrointestinal stromal tumor and colon adenocarcinoma were confirmed. Papillary renal cell carcinoma is a type of renal carcinoma that can be often accurately diagnosed by FNA. The occurrence of associated visceral malignancies has never been reported. The possible role of the protooncogene c-met in the development of these tumors was explored.
乳头状肾细胞癌是一种罕见的肾脏恶性肿瘤。已描述了该肿瘤的细胞遗传学特征以及原癌基因c-met的突变。与乳头状肾细胞癌同时发生的继发性恶性肿瘤很少见，且通常起源于泌尿生殖道。我们描述了两例乳头状肾细胞癌与另外两种内脏恶性肿瘤，即胃肠道间质瘤和结肠腺癌同时发生的病例。回顾了两例经细针穿刺抽吸（FNA）诊断的乳头状肾细胞癌病例，它们与胃肠道恶性肿瘤同时发生。两次抽吸物均显示出乳头状肾细胞癌的特征性细胞学特征，即乳头状结构、泡沫状组织细胞、胞浆内含铁血黄素和核沟。随后的组织学和免疫组化染色支持了细胞学诊断。胃肠道间质瘤和结肠腺癌的组织学诊断得到证实。乳头状肾细胞癌是一种通常可通过FNA准确诊断的肾癌类型。从未有过相关内脏恶性肿瘤同时发生的报道。探讨了原癌基因c-met在这些肿瘤发生中的可能作用。
