Smith Cristina A, Magenis R Ellen, Himoe Eleanor, Smith Cheree, Mansoor Atiya
Department of Pathology, Oregon Health and Sciences University, Portland, OR 97239, USA.
Cancer Genet Cytogenet. 2006 Dec;171(2):97-100. doi: 10.1016/j.cancergencyto.2006.05.018.
Chondromyxoid fibroma is an uncommon benign cartilaginous tumor that rarely presents in the sino-nasal region as a locally destructive, erosive lesion. Both clinically and histologically, it is a difficult diagnosis and can be confused with malignant processes such as myxoid chondrosarcoma. Histology of the tumor, especially with a small sample, can be challenging because of its heterogeneous nature showing an admixture of fibrous, myxoid, and chondroid areas. We are reporting unique cytogenetic findings in a case of chondromyxoid fibroma involving the floor of the nasal cavity with a clonal rearrangement between chromosomes 6 and 19. To our knowledge, karyotypes of 14 cases are reported in literature, with 11 cases reporting nonrandom, clonal abnormalities of chromosome 6. These results illustrate the distinctive nature of this tumor and may help identify genes involved in the pathogenesis of this tumor.
软骨黏液样纤维瘤是一种罕见的良性软骨肿瘤，很少以局部破坏性、侵蚀性病变的形式出现在鼻窦区域。在临床和组织学上，它都是一种难以诊断的疾病，可能会与黏液样软骨肉瘤等恶性病变相混淆。由于肿瘤组织学具有异质性，表现为纤维、黏液样和软骨样区域的混合，尤其是在小样本情况下，其组织学诊断可能具有挑战性。我们报告了一例累及鼻腔底部的软骨黏液样纤维瘤的独特细胞遗传学发现，该肿瘤存在6号和19号染色体之间的克隆性重排。据我们所知，文献中报道了14例该肿瘤的核型，其中11例报告了6号染色体的非随机、克隆性异常。这些结果说明了这种肿瘤的独特性质，可能有助于识别参与该肿瘤发病机制的基因。
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