普伐他汀对接受抗逆转录病毒治疗的血脂异常HIV感染患者颈动脉结构和功能的影响。

Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy.

作者信息

Boccara Franck, Simon Tabassome, Lacombe Karine, Cohen Ariel, Laloux Brigitte, Bozec Erwan, Durant Stéphanie, Girard Pierre-Marie, Laurent Stéphane, Boutouyrie Pierre

机构信息

Department of Pharmacology, Université Paris-Descartes, Faculté de Médecine, INSERM 652, Hôpital Européen Georges Pompidou, Paris, France.

出版信息

AIDS. 2006 Nov 28;20(18):2395-8. doi: 10.1097/QAD.0b013e32801120e3.

DOI:10.1097/QAD.0b013e32801120e3

PMID:17117030

Abstract

Forty-two pravastatin-treated HIV-positive patients and 42 sex, age, and smoking status-matched hypercholesterolemic HIV-positive patients not under lipid-lowering treatment were compared for differences in intima-media thickness (IMT) of the common carotid artery (CCA) and aortic stiffness. Pravastatin had no influence on carotid artery structure and function, or aortic stiffness. Age and body mass index were independent determinants of IMT of the CCA. Mean arterial pressure, age, duration of HIV infection and protease inhibitor exposure determined aortic stiffness.

摘要

对42例接受普伐他汀治疗的HIV阳性患者和42例年龄、性别及吸烟状况相匹配但未接受降脂治疗的高胆固醇血症HIV阳性患者，比较其颈总动脉（CCA）内膜中层厚度（IMT）及主动脉僵硬度的差异。普伐他汀对颈动脉结构和功能或主动脉僵硬度无影响。年龄和体重指数是颈总动脉IMT的独立决定因素。平均动脉压、年龄、HIV感染持续时间及蛋白酶抑制剂暴露情况决定主动脉僵硬度。