调节激活正常T细胞表达和分泌因子（RANTES）的启动子多态性与特应性皮炎相关。

Upregulating promoter polymorphisms of RANTES relate to atopic dermatitis.

作者信息

Tanaka K, Roberts M H, Yamamoto N, Sugiura H, Uehara M, Hopkin J M

机构信息

Experimental Medicine Unit, School of Medicine, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK.

出版信息

Int J Immunogenet. 2006 Dec;33(6):423-8. doi: 10.1111/j.1744-313X.2006.00635.x.

DOI:10.1111/j.1744-313X.2006.00635.x

PMID:17117952

Abstract

It has been reported that a functional polymorphism in the promoter of the RANTES gene (-403G/A) is associated with atopic dermatitis in a German population. Although there are several reports on the association of RANTES promoter polymorphisms (-403G/A and -28C/G) with asthma, the association of these polymorphisms with atopic dermatitis has not yet been confirmed in other populations. We therefore aimed to test whether the RANTES promoter polymorphisms relate to atopic dermatitis in a well-defined Japanese population. We conducted an association study of upregulating promoter polymorphisms of RANTES (-403G/A and -28C/G) in 389 patients with atopic dermatitis and 177 healthy control subjects. There was a significant association between the upregulating variant of RANTES -28G and atopic dermatitis, while -403A variant showed a significant association with atopic dermatitis with high IgE productivity. These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis.

摘要

据报道，RANTES基因启动子中的一个功能性多态性位点（-403G/A）与德国人群的特应性皮炎相关。尽管有几篇关于RANTES启动子多态性位点（-403G/A和-28C/G）与哮喘关联的报道，但这些多态性位点与特应性皮炎的关联在其他人群中尚未得到证实。因此，我们旨在检验RANTES启动子多态性位点是否与明确界定的日本人群中的特应性皮炎相关。我们对389例特应性皮炎患者和177名健康对照者进行了RANTES启动子多态性位点（-403G/A和-28C/G）上调的关联研究。RANTES -28G上调变异体与特应性皮炎之间存在显著关联，而-403A变异体与高IgE产生率的特应性皮炎存在显著关联。这些结果支持RANTES启动子多态性位点在特应性皮炎易感性中起作用。