School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China.
Department of Dermatovenereology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Medicine (Baltimore). 2024 Feb 23;103(8):e36897. doi: 10.1097/MD.0000000000036897.
Atopic dermatitis (AD) is a common and recurrent inflammatory disease with strong genetic susceptibility. The abnormal production of chemokines plays an important role in the occurrence and development of AD.
A comprehensive online literature search was performed in databases of China National Knowledge Infrastructure, Wanfang, VIP China Science and Technology Journal Database, China Biomedical Literature Database, PubMed, Embase and Cochrane Library to retrieve relevant articles published from January 2000 to October 2022. The odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate this relationship.
A total of 7 studies were finally screened out, including 1316 AD patients and 1099 controls. There were 3 studies for CC chemokine ligand 5 (CCL5) polymorphisms, 2 for CCL11 polymorphisms, and 2 for CCL17 polymorphisms, respectively. The meta-analysis revealed a significant association between the CCL5 - 403G/A polymorphism and AD under the allelic model (A vs G: OR = 1.25, 95% CI = 1.02-1.52, P = .03), heterozygous model (AG vs GG: OR = 1.40, 95% CI = 1.08-1.80, P = .01) and dominant model (AA + AG vs GG: OR = 1.38, 95% CI = 1.08-1.76, P = .01) in a fixed-effect model. The allelic model (G vs C: OR = 1.46, 95% CI = 1.07-1.98, P < .01) and dominant model (GG + GC vs CC: OR = 1.74, 95% CI = 1.23-2.47, P < .001) of the CCL5 - 28C/G polymorphism were also associated with an increased risk of AD. However, this significant association was not found in other alleles and genotypes (P > .05).
Our results show that the A allele, AG and AA + AG genotypes of the CCL5 - 403G/A polymorphism, the G allele and GG + GC genotype of the CCL5 - 28C/G polymorphism are risk factors for AD. Future studies with large population are still needed to further explore those correlations.
特应性皮炎（AD）是一种常见的复发性炎症性疾病，具有很强的遗传易感性。趋化因子的异常产生在 AD 的发生和发展中起重要作用。
在中国知网、万方、维普中国科技期刊数据库、中国生物医学文献数据库、PubMed、Embase 和 Cochrane Library 中全面检索 2000 年 1 月至 2022 年 10 月发表的相关文献。采用比值比（OR）及其 95%置信区间（CI）来计算这种关系。
最终筛选出 7 项研究，共纳入 1316 例 AD 患者和 1099 例对照。其中，CC 趋化因子配体 5（CCL5）多态性研究 3 项，CCL11 多态性研究 2 项，CCL17 多态性研究 2 项。荟萃分析显示，在等位基因模型（A 对 G：OR=1.25，95%CI=1.02-1.52，P=0.03）、杂合子模型（AG 对 GG：OR=1.40，95%CI=1.08-1.80，P=0.01）和显性模型（AA+AG 对 GG：OR=1.38，95%CI=1.08-1.76，P=0.01）下，CCL5-403G/A 多态性与 AD 相关。CCL5-28C/G 多态性的等位基因模型（G 对 C：OR=1.46，95%CI=1.07-1.98，P<0.01）和显性模型（GG+GC 对 CC：OR=1.74，95%CI=1.23-2.47，P<0.001）也与 AD 风险增加相关。然而，其他等位基因和基因型（P>0.05）未发现这种显著关联。
我们的研究结果表明，CCL5-403G/A 多态性的 A 等位基因、AG 和 AA+AG 基因型，CCL5-28C/G 多态性的 G 等位基因和 GG+GC 基因型是 AD 的危险因素。未来仍需要进行大样本的研究以进一步探讨这些相关性。
