趋化因子多态性与淋巴瘤：一项荟萃分析。
Chemokine polymorphisms and lymphoma: a pooled analysis.
机构信息
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94118-1944, USA.
出版信息
Leuk Lymphoma. 2010 Mar;51(3):497-506. doi: 10.3109/10428190903518337.
Polymorphisms in chemokine genes have been associated with human immunodeficiency virus (HIV)-related non-Hodgkin lymphoma (NHL) but are understudied in non-HIV-related NHL. Associations of NHL and NHL subtypes with polymorphisms and haplotypes in CCR5, CCR2, CCL5, CXCL12, and CX(3)CR(1) were explored in a pooled analysis of three case-control studies (San Francisco Bay Area, California; United Kingdom; total: cases N = 1610, controls N = 1992). Adjusted unconditional logistic regression was used to estimate relative risks among HIV-negative non-Hispanic Caucasians. The CCR5 Delta32 deletion reduced the risk of NHL (odds ratio = 0.56, 95% confidence interval = 0.38-0.83) in men but not women with similar effects observed for diffuse large-cell and follicular lymphoma (FL). NHL risk also was reduced in men with the CCR2/CCR5 haplotype characterized by the CCR5 Delta32 deletion. The CCL5 -403A allele conferred reduced risks of FL and chronic lymphocytic leukemia/small lymphocytic lymphoma. Results should be interpreted conservatively. Continued investigation is warranted to confirm these findings.
趋化因子基因多态性与人类免疫缺陷病毒（HIV）相关的非霍奇金淋巴瘤（NHL）有关，但在非 HIV 相关 NHL 中的研究较少。在对三个病例对照研究（加利福尼亚旧金山湾区；英国；总计：病例 N = 1610，对照 N = 1992）的汇总分析中，探讨了 NHL 和 NHL 亚型与 CCR5、CCR2、CCL5、CXCL12 和 CX（3）CR（1）中的多态性和单倍型之间的关联。调整后的非条件逻辑回归用于估计 HIV 阴性非西班牙裔白种人中的相对风险。CCR5 Delta32 缺失降低了 NHL（比值比 = 0.56，95%置信区间 = 0.38-0.83）的风险，在男性中，但对弥漫性大细胞和滤泡性淋巴瘤（FL）的影响相似。具有 CCR5 Delta32 缺失特征的 CCR2/CCR5 单倍型也降低了男性 NHL 的风险。CCL5 -403A 等位基因降低了 FL 和慢性淋巴细胞白血病/小淋巴细胞淋巴瘤的风险。结果应谨慎解释。需要进一步研究来证实这些发现。
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