McDougall Jason J
Department of Physiology & Biophysics, University of Calgary, Hospital Drive, Calgary, Alberta, T2N 4N1, Canada.
Arthritis Res Ther. 2006;8(6):220. doi: 10.1186/ar2069.
Arthritis pain affects millions of people worldwide yet we still have only a limited understanding of what makes our joints ache. This review examines the sensory innervation of diarthroidal joints and discusses the neurophysiological processes that lead to the generation of painful sensation. During inflammation, joint nerves become sensitized to mechanical stimuli through the actions of neuropeptides, eicosanoids, proteinase-activated receptors and ion channel ligands. The contribution of immunocytes to arthritis pain is also reviewed. Finally, the existence of an endogenous analgesic system in joints is considered and the reasons for its inability to control pain are postulated.
关节炎疼痛影响着全球数百万人,但我们对导致关节疼痛的原因仍知之甚少。本文综述了滑膜关节的感觉神经支配,并讨论了导致疼痛感觉产生的神经生理过程。在炎症过程中,关节神经通过神经肽、类花生酸、蛋白酶激活受体和离子通道配体的作用对机械刺激变得敏感。本文还综述了免疫细胞在关节炎疼痛中的作用。最后,探讨了关节内源性镇痛系统的存在,并推测了其无法控制疼痛的原因。