Amt/MEP/Rh家族：AmtB的结构与氨气传导机制
The Amt/MEP/Rh family: structure of AmtB and the mechanism of ammonia gas conduction.
作者信息
Khademi Shahram, Stroud Robert M
机构信息
Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, California, USA.
出版信息
Physiology (Bethesda). 2006 Dec;21:419-29. doi: 10.1152/physiol.00051.2005.
The atomic structures of the first members of the Amt/MEP/Rh family show that they are 11-crossing membrane proteins that form trimers in the membrane. Each monomer supports a hydrophobic channel that conducts NH(3) but not any water or ions. The reprotonation of NH(3) on the receiving side raises the pH on that side in the absence of metabolism of NH(3), and there is no transfer of protons through the protein.
Amt/MEP/Rh家族首批成员的原子结构表明，它们是11次跨膜蛋白，在膜中形成三聚体。每个单体都支持一个疏水通道，该通道传导NH₃，但不传导任何水或离子。在没有NH₃代谢的情况下，NH₃在接收侧的再质子化会提高该侧的pH值，并且质子不会通过该蛋白质进行转移。
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