Mehlman Myron A
Department of Medicine, The Mount Sinai Medical Center, New York, NY, USA.
Ann N Y Acad Sci. 2006 Sep;1076:110-9. doi: 10.1196/annals.1371.065.
Benzene and benzene-containing products and solvents have long been associated with bone marrow toxicity. Both animal studies and human epidemiological studies have shown statistically significant increases of leukemia and other lymphohematopoietic cancers in workers exposed to benzene. The most common leukemia that has been associated with benzene exposure, also called benzene poisoning, is acute myelocytic leukemia (AML). A review of the epidemiological literature on workers exposed to benzene or benzene-containing solvents and products shows, without question, that this exposure is significantly related to other types of leukemia and lymphoma. In this article, we review the literature on the relationship between benzene exposure and chronic myelogenous leukemia (CML) and find that benzene and benzene-containing products are significantly related to morbidity and mortality from CML.
长期以来，苯及含苯产品和溶剂一直与骨髓毒性有关。动物研究和人类流行病学研究均表明，接触苯的工人患白血病和其他淋巴造血系统癌症的几率在统计学上有显著增加。与接触苯（也称为苯中毒）相关的最常见白血病是急性髓细胞白血病（AML）。对接触苯或含苯溶剂及产品的工人的流行病学文献进行综述后发现，毫无疑问，这种接触与其他类型的白血病和淋巴瘤有显著关联。在本文中，我们回顾了关于苯接触与慢性粒细胞白血病（CML）之间关系的文献，发现苯及含苯产品与CML的发病率和死亡率有显著关联。
