Yin S N, Hayes R B, Linet M S, Li G L, Dosemeci M, Travis L B, Li C Y, Zhang Z N, Li D G, Chow W H, Wacholder S, Wang Y Z, Jiang Z L, Dai T R, Zhang W Y, Chao X J, Ye P Z, Kou Q R, Zhang X C, Lin X F, Meng J F, Ding C Y, Zho J S, Blot W J
Chinese Academy of Preventive Medicine, Institute of Occupational Medicine, Beijing, China.
Am J Ind Med. 1996 Mar;29(3):227-35. doi: 10.1002/(SICI)1097-0274(199603)29:3<227::AID-AJIM2>3.0.CO;2-N.
A large cohort study of 74,828 benzene-exposed and 35,805 unexposed workers employed between 1972 and 1987 in 12 cities in China were followed to determine mortality from all causes and the incidence of lymphohematopoietic malignancies and other hematologic disorders. Benzene-exposed study subjects were employed in a variety of occupations, including painting, printing, and the manufacture of footwear, paint, and other chemicals. All-cause mortality was similar in the benzene-exposed and unexposed comparison group. Statistically significant excess deaths were noted among benzene-exposed subjects for leukemia (RR = 2.3, 95% CP 1.1-5.0), malignant lymphoma (RR = 4.5, 95% CI: 1.3-28.4), and nonneoplastic diseases of the blood (RR = 95% CP 2.5-infinity), and a marginally significant excess was noted for lung cancer (RR = 1.4, 95% CI: 1.0-2.0). Risk was significantly elevated for the incidence of all lymphohematopoietic malignancies (RR = 2.6, 95% CI: 1.5-5.0), malignant lymphoma (RR = 3.5, 95% CI: 1.2-14.9), and leukemia (RR = 2.6, 95% CI.. 1.3-5.7). Among the leukemia subtypes, only acute myelogenous leukemia (AML) incidence was significantly elevated (RR = 3.1, 95% CI: 1.2-10.7), although nonsignificant excesses were also noted for chronic myelogenous leukemia (CML) (RR = 2.6, 95% CI: 0.7-16.9) and lymphocytic leukemias (RR = 2.8, 95% CI.. 0.5-54.5). Significant excesses were found for aplastic anemia (RR = infinity, 95% CI: 2.2-co) and myelodysplastic syndrome (RR = infinity, 95% CI: 1.7-infinity). Employment in benzene-associated occupations in China is associated with a wide spectrum of myelogenous and lymphocytic malignant diseases and related disorders. Investigations continue to assess the nature of these associations.
一项针对1972年至1987年间在中国12个城市工作的74828名接触苯的工人和35805名未接触苯的工人的大型队列研究，旨在确定全因死亡率以及淋巴造血系统恶性肿瘤和其他血液疾病的发病率。接触苯的研究对象从事多种职业，包括油漆、印刷以及鞋类、油漆和其他化学品的制造。接触苯组和未接触苯的对照组的全因死亡率相似。在接触苯的人群中，白血病（相对危险度RR = 2.3，95%可信区间CP 1.1 - 5.0）、恶性淋巴瘤（RR = 4.5，95%可信区间CI：1.3 - 28.4）和血液非肿瘤性疾病（RR = 95% CP 2.5 - 无穷大）的死亡人数有统计学意义的显著增加，肺癌的死亡人数有边缘性显著增加（RR = 1.4，95%可信区间CI：1.0 - 2.0）。所有淋巴造血系统恶性肿瘤（RR = 2.6，95%可信区间CI：1.5 - 5.0）、恶性淋巴瘤（RR = 3.5，95%可信区间CI：1.2 - 14.9）和白血病（RR = 2.6，95%可信区间CI：1.3 - 5.7）的发病率风险显著升高。在白血病亚型中，只有急性髓系白血病（AML）的发病率显著升高（RR = 3.1，95%可信区间CI：1.2 - 10.7），尽管慢性髓系白血病（CML）（RR = 2.6，95%可信区间CI：0.7 - 16.9）和淋巴细胞白血病（RR = 2.8，95%可信区间CI：0.5 - 54.5）也有非显著性增加。再生障碍性贫血（RR = 无穷大，95%可信区间CI：2.2 - 无穷大）和骨髓增生异常综合征（RR = 无穷大，95%可信区间CI：1.7 - 无穷大）的发病率有显著增加。在中国，从事与苯相关职业与多种髓系和淋巴细胞恶性疾病及相关疾病有关。调查仍在继续评估这些关联的性质。
