Hachulla E, Saile R, Parra H J, Hatron P Y, Gosset D, Fruchart J C, Devulder B
Service de Médecine Interne, CHU Hôpital Claude Huriez, Lille, France.
Clin Exp Rheumatol. 1991 Mar-Apr;9(2):157-63.
A prospective clinical study of 23 patients with giant-cell arteritis (GCA) and/or polymyalgia rheumatica (PMR) was undertaken in order to assess the behaviour of the non-specific markers of the disease activity, the erythrocyte sedimentation rate (ESR) and other acute phase markers, particularly the C-reactive protein (CPR) and serum amyloid A apolipoprotein (apo SAA) levels during induction of disease remission by prednisone therapy, and possible further recurrence of GCA and/or PMR. The apo SAA measurement is more sensitive than the CRP measurement in determining disease activity (97% and 61%, respectively). The specificity of apo SAA is greater than ESR in the determination of inactive disease (86% and 77%, respectively). In some cases with clinically active disease the ESR and CRP were normal, whereas the apo SAA was always elevated. We conclude that the apo SAA measurement in combination with clinical data and other laboratory parameters may be useful in the management of GCA and/or PMR.
对23例巨细胞动脉炎（GCA）和/或风湿性多肌痛（PMR）患者进行了一项前瞻性临床研究，以评估疾病活动的非特异性标志物、红细胞沉降率（ESR）和其他急性期标志物的变化情况，特别是在泼尼松治疗诱导疾病缓解期间C反应蛋白（CPR）和血清淀粉样蛋白A载脂蛋白（apo SAA）的水平，以及GCA和/或PMR可能的进一步复发情况。在确定疾病活动方面，apo SAA测量比CRP测量更敏感（分别为97%和61%）。在确定疾病非活动状态时，apo SAA的特异性高于ESR（分别为86%和77%）。在一些临床活动期疾病的病例中，ESR和CRP正常，而apo SAA总是升高。我们得出结论，apo SAA测量结合临床数据和其他实验室参数可能有助于GCA和/或PMR的管理。
