Dorta-Contreras Alberto Juan, Noris-García Elena, Padilla-Docal Bárbara, Rodríguez-Rey Alexis, Bu-Coifiu-Fanego Raisa, Magraner-Tarrau María Esther, Martí-Brenes Mauricio
Laboratorio Central Liquido Cefalorraquideo (LABCEL), Ciudad de La Habana, Cuba.
Arq Neuropsiquiatr. 2006 Sep;64(3A):585-8. doi: 10.1590/s0004-282x2006000400010.
Reiber's quotient diagram or reibergram has a growing apply for characterize the intratecal synthesis of proteins. Firstly reibergrama was used for the major classes of immunoglobulins but later it was used to evaluate other proteins based on the theory about molecular flux/cerebrospinal fluid (CSF) flow rate.
C3c is a degradation product of complement factor C3 with 145 KDa and approaches to IgG molecular characteristics according with Fick's diffusion laws. It was assumed IgG constants and graphic for IgG constants and graphic to evaluate the intrathecal synthesis of C3c. Twenty-seven patients and 27 controls were studied. Serum and CSF C3c and albumin were quantified by immunodiffusion.
The patients with the C3c proposed reibergram were evaluated. It has been proved its validity under several CSF blood barrier conditions.
Reibergram for C3c can be used for the evaluation of the intrathecal synthesis of this protein.
赖伯商数图或赖伯格图在表征鞘内蛋白质合成方面的应用日益广泛。最初，赖伯格图用于主要类别的免疫球蛋白，但后来基于分子通量/脑脊液（CSF）流速理论，它被用于评估其他蛋白质。
C3c是补体因子C3的降解产物，分子量为145 kDa，根据菲克扩散定律，其分子特征与IgG相似。假定IgG常数以及IgG常数的图表用于评估C3c的鞘内合成。研究了27例患者和27名对照。通过免疫扩散法定量血清和脑脊液中的C3c和白蛋白。
对采用C3c的赖伯格图的患者进行了评估。已证明其在多种脑脊液血脑屏障条件下的有效性。
C3c的赖伯格图可用于评估该蛋白质的鞘内合成。
