Annunziata P, Volpi N
Acta Neurol Scand. 1985 Jul;72(1):61-4. doi: 10.1111/j.1600-0404.1985.tb01548.x.
A study of several parameters of the humoral immunity in the serum and the cerebrospinal fluid (CSF) of thirteen Amyotrophic Lateral Sclerosis (ALS) patients was carried out. A significant increase in CSF C3c was shown. This feature was found to be significantly correlated to the CSF albumin/serum albumin ration (r = 0.70; p less than 0.05) and to the total CSF proteins (r = 0.86; p less than 0.01). The possible effect of the blood-brain barrier breakdown on the CSF complement levels was evaluated. On the basis of the recently found biochemical changes in ALS cell membranes it is proposed that the high levels of the CSF C3c may also be due to a defective binding to the lymphocytes C3 receptors.
对13例肌萎缩侧索硬化症（ALS）患者血清和脑脊液（CSF）中的体液免疫若干参数进行了研究。结果显示脑脊液C3c显著增加。发现这一特征与脑脊液白蛋白/血清白蛋白比值显著相关（r = 0.70；p < 0.05），与脑脊液总蛋白也显著相关（r = 0.86；p < 0.01）。评估了血脑屏障破坏对脑脊液补体水平的可能影响。基于最近在ALS细胞膜中发现的生化变化，有人提出脑脊液C3c水平升高也可能是由于与淋巴细胞C3受体结合存在缺陷。
