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染色质重塑与DNA双链断裂的修复

Chromatin remodeling and repair of DNA double-strand breaks.

作者信息

Wong Lai-Yee, Recht Judith, Laurent Brehon C

机构信息

Department of Oncological Sciences, Mount Sinai School of Medicine, Icahn Medical Institute, 1425 Madison Ave., New York, NY 10029, USA.

出版信息

J Mol Histol. 2006 Sep;37(5-7):261-9. doi: 10.1007/s10735-006-9047-4. Epub 2006 Aug 8.

DOI:10.1007/s10735-006-9047-4
PMID:17120107
Abstract

Eukaryotic cells have developed conserved mechanisms to efficiently sense and repair DNA damage that results from constant chromosomal lesions. DNA repair has to proceed in the context of chromatin, and both histone-modifiers and ATP-dependent chromatin remodelers have been implicated in this process. Here, we review the current understanding and new hypotheses on how different chromatin-modifying activities function in DNA repair in yeast and metazoan cells.

摘要

真核细胞已经进化出保守机制，以有效感知和修复由持续的染色体损伤导致的DNA损伤。DNA修复必须在染色质的背景下进行，组蛋白修饰因子和ATP依赖的染色质重塑因子都参与了这一过程。在这里，我们综述了目前对于酵母和后生动物细胞中不同染色质修饰活性如何在DNA修复中发挥作用的理解以及新的假说。

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本文引用的文献

1
Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis.组蛋白伴侣Asf1是组蛋白H3赖氨酸56乙酰化所必需的，这种修饰与有丝分裂和减数分裂中的S期相关。
Proc Natl Acad Sci U S A. 2006 May 2;103(18):6988-93. doi: 10.1073/pnas.0601676103. Epub 2006 Apr 20.
2
The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4.酿酒酵母组蛋白H2A变体Htz1被NuA4乙酰化。
Genes Dev. 2006 Mar 15;20(6):660-5. doi: 10.1101/gad.1388106.
3
Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex.
Set3复合物在DNA损伤反应中拮抗MYST乙酰转移酶Esa1。
Mol Cell Biol. 2015 Nov;35(21):3714-25. doi: 10.1128/MCB.00298-15. Epub 2015 Aug 24.
4
Mechanisms of nanosilver-induced toxicological effects: more attention should be paid to its sublethal effects.纳米银诱导毒理效应的机制：应更多关注其亚致死效应。
Nanoscale. 2015 May 7;7(17):7470-81. doi: 10.1039/c5nr01133g.
5
A moonlighting metabolic protein influences repair at DNA double-stranded breaks.一种兼职代谢蛋白影响DNA双链断裂处的修复。
Nucleic Acids Res. 2015 Feb 18;43(3):1646-58. doi: 10.1093/nar/gku1405. Epub 2015 Jan 27.
6
Singular v dual inhibition of SNF2L and its isoform, SNF2LT, have similar effects on DNA damage but opposite effects on the DNA damage response, cancer cell growth arrest and apoptosis.对SNF2L及其同种型SNF2LT的单一抑制与双重抑制对DNA损伤具有相似的作用，但对DNA损伤反应、癌细胞生长停滞和凋亡具有相反的作用。
Oncotarget. 2012 Apr;3(4):475-89. doi: 10.18632/oncotarget.479.
7
RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks.RSC 通过促进黏连蛋白在 DNA 双链断裂处的加载，促进姐妹染色单体之间 Rad59 依赖性同源重组。
Mol Cell Biol. 2011 Oct;31(19):3924-37. doi: 10.1128/MCB.01269-10. Epub 2011 Aug 1.
8
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Nucleic Acids Res. 2011 Oct;39(19):8378-91. doi: 10.1093/nar/gkr535. Epub 2011 Jul 11.
9
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10
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Biochem Cell Biol. 2011 Feb;89(1):12-23. doi: 10.1139/O10-114.
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4
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Nat Cell Biol. 2006 Jan;8(1):91-9. doi: 10.1038/ncb1343. Epub 2005 Dec 11.
5
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Mol Cell. 2005 Dec 9;20(5):801-9. doi: 10.1016/j.molcel.2005.10.003. Epub 2005 Nov 28.
6
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Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17745-50. doi: 10.1073/pnas.0509014102. Epub 2005 Nov 21.
7
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.一种使γH2AX去磷酸化的磷酸酶复合物调控DNA损伤检查点恢复。
Nature. 2006 Jan 26;439(7075):497-501. doi: 10.1038/nature04384. Epub 2005 Nov 20.
8
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Biochem Biophys Res Commun. 2006 Jan 6;339(1):313-20. doi: 10.1016/j.bbrc.2005.10.206. Epub 2005 Nov 15.
9
Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae.酿酒酵母中DNA双链断裂位点处的染色质重塑
Nature. 2005 Nov 17;438(7066):379-83. doi: 10.1038/nature04148.
10
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