Osborne P J, Lee L W
Department of Anesthesiology, University of British Columbia, Vancouver.
Can J Anaesth. 1991 May;38(4 Pt 1):499-501. doi: 10.1007/BF03007588.
A patient with idiopathic orthostatic hypotension receiving chronic oral midodrine therapy required anaesthesia for coronary artery bypass grafting. A perioperative infusion of phenylephrine was substituted for midodrine, an alpha-2 agonist, enabling hypotension resulting from low systemic vascular resistance to be controlled easily. Anticipated adrenergic receptor denervation hypersensitivity was noted. The only significant perioperative problem was one episode of syncope from orthostatic hypotension during the reambulation period.
一名接受慢性口服米多君治疗的特发性直立性低血压患者需要进行冠状动脉搭桥手术麻醉。术中用去氧肾上腺素输注替代了α-2激动剂米多君，从而轻松控制了因体循环血管阻力降低导致的低血压。注意到预期的肾上腺素能受体去神经超敏反应。围手术期唯一显著的问题是在恢复活动期间发生了一次因直立性低血压导致的晕厥。
