Schirger A, Sheps S G, Thomas J E, Fealey R D
Mayo Clin Proc. 1981 Jul;56(7):429-33.
Five patients with idiopathic orthostatic hypotension, two of whom had central nervous system manifestations (Shy-Drager syndrome), were treated with midodrine, an investigational alpha-adrenergic agonist, in a dosage of 2.5 to 5 mg three times daily. Significant improvement was observed in the standing systolic and diastolic blood pressures at the end of 1 week of therapy in all patients and has been maintained for 10 to 15 months in all patients. No symptomatic side effects were noted. Supine systolic hypertension occurred in two patients and was treated with small doses of metoprolol.
五名特发性直立性低血压患者，其中两名有中枢神经系统表现（Shy-Drager综合征），接受了米多君治疗，米多君是一种正在研究的α-肾上腺素能激动剂，剂量为每日三次，每次2.5至5毫克。所有患者在治疗1周结束时，站立位收缩压和舒张压均有显著改善，且在所有患者中已维持10至15个月。未观察到有症状的副作用。两名患者出现仰卧位收缩期高血压，用小剂量美托洛尔进行了治疗。
