抑制剂对线粒体内膜通道的选择性作用。

Selective effect of inhibitors on inner mitochondrial membrane channels.

作者信息

Antonenko Y N, Kinnally K W, Perini S, Tedeschi H

机构信息

Department of Bioenergetics, A.N. Belozersky Laboratory, Moscow State University, USSR.

出版信息

FEBS Lett. 1991 Jul 8;285(1):89-93. doi: 10.1016/0014-5793(91)80731-h.

DOI:10.1016/0014-5793(91)80731-h

PMID:1712321

Abstract

The effect of amphiphilic cationic drugs on the channel activity of the mitochondrial inner membrane was examined with patch-clamp techniques. The therapeutic drugs amiodarone, propranolol and quinine reduced the probability of being open for the multiconductance channel (MCC) activity (levels from 30 pS to over 1 nS). While amiodarone decreased the probability of being open for the voltage dependent approximately 100 pS channel, it increased the conductance 42 +/- 20% (mean +/- SD, n = 6) with no significant change in mean open time. Similar results were obtained with propranolol. These data indicate that the approximately 100 pS channel is distinct from MCC activity.

摘要

采用膜片钳技术研究了两亲性阳离子药物对线粒体内膜通道活性的影响。治疗药物胺碘酮、普萘洛尔和奎宁降低了多电导通道（MCC）活性（电导水平从30 pS到超过1 nS）开放的概率。虽然胺碘酮降低了电压依赖性约100 pS通道开放的概率，但它使电导增加了42±20%（平均值±标准差，n = 6），平均开放时间无显著变化。普萘洛尔也得到了类似的结果。这些数据表明，约100 pS通道与MCC活性不同。