Kinnally K W, Lohret T A, Campo M L, Mannella C A
Division of Molecular Medicine, Wadsworth Center, Empire State Plaza, Albany, New York 12201-0509, USA.
J Bioenerg Biomembr. 1996 Apr;28(2):115-23. doi: 10.1007/BF02110641.
A multiple conductance channel (MCC) with a peak conductance of over 1 nS is recorded from mitoplasts (mitochondria with the inner membrane exposed) using patch-clamp techniques. MCC shares many general characteristics with other intracellular megachannels, many of which are weakly selective, voltage-dependent, and calcium sensitive. A role in protein import is suggested by the transient blockade of MCC by peptides responsible for targeting mitochondrial precursor proteins. MCC is compared with the peptide-sensitive channel of the outer membrane because of similarities in targeting peptide blockade. The pharmacology and regulation of MCC by physiological effectors are reviewed and compared with the properties of the pore hypothesized to be responsible for the mitochondrial inner membrane permeability transition.
使用膜片钳技术从线粒体质（内膜暴露的线粒体）中记录到一种峰值电导超过1 nS的多电导通道（MCC）。MCC与其他细胞内大通道具有许多共同特征，其中许多通道具有弱选择性、电压依赖性和钙敏感性。负责靶向线粒体前体蛋白的肽对MCC的短暂阻断提示其在蛋白质导入中发挥作用。由于在靶向肽阻断方面的相似性，将MCC与外膜的肽敏感通道进行了比较。综述了生理效应器对MCC的药理学和调节作用，并与假定负责线粒体内膜通透性转变的孔道特性进行了比较。
