New York University College of Dentistry, New York, NY 10010, USA.
FEBS Lett. 2010 May 17;584(10):2142-52. doi: 10.1016/j.febslet.2010.02.046. Epub 2010 Feb 20.
The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential.
线粒体离子通道的研究改变了我们对这些双层细胞器的认识，使其不再仅仅是细胞的“能量工厂”，而是细胞命运的守护者。线粒体通过这些特殊的通道与细胞进行通讯。大多数时候，信息是由穿过线粒体内外膜的离子流编码的。钾、钠、钙、质子、核苷酸和蛋白质以极其精确的方式穿过线粒体膜，以控制从呼吸到线粒体形态，再到细胞增殖和细胞死亡等无数过程。这篇综述更新了关于已确立和推测的线粒体通道的组成、功能、调节和治疗潜力的信息。
