Siedentopf Christian M, Ischebeck Anja, Haala Ilka A, Mottaghy Felix M, Schikora Detlef, Verius Michael, Koppelstaetter Florian, Buchberger Waltraud, Schlager Andreas, Felber Stephan R, Golaszewski Stefan M
Department of Radiology II, Division of Neuroradiology, University Hospital of Innsbruck, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Neurosci Lett. 2007 Jan 16;411(3):189-93. doi: 10.1016/j.neulet.2006.08.049. Epub 2006 Nov 22.
Transmeatal cochlear laser (TCL) treatment has recently been proposed as a therapeutic procedure for cochlear dysfunction such as chronic cochlear tinnitus or sensorineural hearing loss. The aim of this study was to investigate whether TLC has any influence on the central nervous system using functional MRI with healthy young adults. The laser stimulation device was placed on the tympanic membrane of both ears. A laser stimulation run and a placebo run were performed in random order. The participants were unable to differentiate between verum and placebo stimulation. In the comparison of verum to placebo runs, we observed significant activations within the left superior frontal gyrus, the right middle and medial frontal gyrus, the right superior parietal lobule, the left superior occipital gyrus, the precuneus and cuneus bilaterally, the right anterior and the left and right middle and posterior cingulate gyrus and the left thalamus. This network of brain areas corresponds well to results from previous PET studies of patients with tinnitus. Though TCL seems to have a clinically measurable effect on the central nervous system the neurophysiological mechanism leading to the observed activated neuronal network remains unknown.
经耳道耳蜗激光（TCL）治疗最近被提议作为一种治疗耳蜗功能障碍的方法，如慢性耳蜗性耳鸣或感音神经性听力损失。本研究的目的是使用功能磁共振成像对健康的年轻人进行研究，以调查TCL是否对中枢神经系统有任何影响。激光刺激装置放置在双耳的鼓膜上。激光刺激运行和安慰剂运行以随机顺序进行。参与者无法区分真实刺激和安慰剂刺激。在真实刺激与安慰剂运行的比较中，我们观察到左侧额上回、右侧额中回和额内侧回、右侧顶上小叶、左侧枕上回、双侧楔前叶和楔叶、右侧前扣带回以及左侧和右侧中后扣带回和左侧丘脑有显著激活。这个脑区网络与先前对耳鸣患者的PET研究结果非常吻合。尽管TCL似乎对中枢神经系统有临床可测量的影响，但导致观察到的激活神经元网络的神经生理机制仍然未知。
