Gorospe Emmanuel C, Dave Jatin K
Division of Aging, Brigham and Women's Hospital/Harvard Medical School, 1620 Tremont Street, Boston, USA.
Age Ageing. 2007 Jan;36(1):23-9. doi: 10.1093/ageing/afl123. Epub 2006 Nov 23.
identification of modifiable risk factors is crucial in the prevention of dementia, given its limited treatment options. Studies on increased body mass index (BMI) as a risk factor for dementia show conflicting results.
we systematically retrieved and reviewed longitudinal population-based studies on increased BMI and dementia using a standard protocol. We searched Medline (1966-2006), Ageline (1978-2006), PsychInfo (1966-2006), CINAHL (1982-2006), and other relevant databases, including the reference lists of the eligible articles for review. Included studies were subjected to a quality assessment protocol.
we identified eight studies that met our selection criteria. These studies covered 1,688 cases of dementia from 28,697 participants. After adjustment for age, smoking, comorbidities, and other confounders, four studies presented significantly increased risk of dementia with elevated BMI.
this systematic review supports the hypothesis that increased BMI is independently associated with increased risk of dementia. Long-term studies to examine the mechanisms underlying the relationship between obesity and dementia are needed.
鉴于痴呆症的治疗选择有限，识别可改变的风险因素对预防痴呆症至关重要。关于体重指数（BMI）升高作为痴呆症风险因素的研究结果相互矛盾。
我们使用标准方案系统检索并回顾了基于人群的关于BMI升高与痴呆症的纵向研究。我们检索了Medline（1966 - 2006年）、Ageline（1978 - 2006年）、PsychInfo（1966 - 2006年）、CINAHL（1982 - 2006年）以及其他相关数据库，包括符合审查条件文章的参考文献列表。纳入的研究需遵循质量评估方案。
我们确定了八项符合我们选择标准的研究。这些研究涵盖了来自28,697名参与者中的1,688例痴呆症病例。在对年龄、吸烟、合并症及其他混杂因素进行调整后，四项研究表明BMI升高会显著增加患痴呆症的风险。
本系统评价支持BMI升高与痴呆症风险增加独立相关这一假设。需要进行长期研究以探究肥胖与痴呆症之间关系的潜在机制。
