对Chong等人、Nishio等人以及Suri等人关于非肥胖糖尿病（NOD）小鼠糖尿病逆转的论文的评论。

Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice.

作者信息

Faustman Denise L, Tran Simon D, Kodama Shohta, Lodde Beatrijs M, Szalayova Ildiko, Key Sharon, Toth Zsuzsanna E, Mezey Eva

机构信息

Massachusetts General Hospital, Charlestown, MA 02129, USA.

出版信息

Science. 2006 Nov 24;314(5803):1243; author reply 1243. doi: 10.1126/science.1129918.

DOI:10.1126/science.1129918

PMID:17124308

Abstract

Chong et al., Nishio et al., and Suri et al. (Reports, 24 March 2006, pp. 1774, 1775, and 1778) confirmed that treating nonobese diabetic (NOD) mice with an immune adjuvant and semisyngenic spleen cells can reverse the disease but found that spleen cells did not contribute to the observed recovery of pancreatic islets. We show that islet regeneration predominately originates from endogenous cells but that introduced spleen cells can also contribute to islet recovery.

摘要

庄等人、西尾等人以及苏里等人（《报告》，2006年3月24日，第1774页、1775页和1778页）证实，用免疫佐剂和半同基因脾细胞治疗非肥胖糖尿病（NOD）小鼠可逆转该疾病，但发现脾细胞对观察到的胰岛恢复并无作用。我们发现，胰岛再生主要源于内源性细胞，但引入的脾细胞也有助于胰岛恢复。