Nishio Junko, Gaglia Jason L, Turvey Stuart E, Campbell Christopher, Benoist Christophe, Mathis Diane
Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA.
Science. 2006 Mar 24;311(5768):1775-8. doi: 10.1126/science.1124004.
A cure for type 1 diabetes will probably require the provision or elicitation of new pancreatic islet beta cells as well as the reestablishment of immunological tolerance. A 2003 study reported achievement of both advances in the NOD mouse model by coupling injection of Freund's complete adjuvant with infusion of allogeneic spleen cells. It was concluded that the adjuvant eliminated anti-islet autoimmunity and the donor splenocytes differentiated into insulin-producing (presumably beta) cells, culminating in islet regeneration. Here, we provide data indicating that the recovered islets were all of host origin, reflecting that the diabetic NOD mice actually retain substantial beta cell mass, which can be rejuvenated/regenerated to reverse disease upon adjuvant-dependent dampening of autoimmunity.
治愈1型糖尿病可能需要提供或诱导新的胰岛β细胞，以及重建免疫耐受。2003年的一项研究报告称，通过将弗氏完全佐剂注射与同种异体脾细胞输注相结合，在非肥胖糖尿病（NOD）小鼠模型中实现了这两项进展。得出的结论是，佐剂消除了抗胰岛自身免疫，供体脾细胞分化为产生胰岛素的（可能是β）细胞，最终导致胰岛再生。在这里，我们提供的数据表明，恢复的胰岛均来自宿主，这反映出糖尿病NOD小鼠实际上保留了大量的β细胞群，在佐剂依赖性自身免疫抑制作用下，这些细胞可以恢复活力/再生以逆转疾病。
