Yong Du, Qing Wu Qing, Hua Liang, Kan Jia Jing, Xi Chen Jia, Jin Qin Qiao, Chao Shen Han
Department of Nephrology, 2nd Affiliated Hospital, School of Medicine, Zhe Jiang University, Hangzhou, PR China.
Am J Nephrol. 2006;26(5):511-8. doi: 10.1159/000097367. Epub 2006 Nov 22.
BACKGROUND/AIMS: The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been extensively examined for the association with immunoglobulin A (IgA) nephropathy (IgAN), however, conflicting results have occurred. We performed a meta-analysis to evaluate the association of ACE I/D polymorphism with IgAN in different ethnic groups.
11 studies testing the association between ACE I/D polymorphism and IgAN susceptibility, and 9 studies testing the association of ACE I/D with IgAN progression were used in this analysis. The overall odds ratio (OR) was estimated by a fixed or random effect model.
The overall OR for the risk of susceptibility and progression of IgAN in Asians for the DD genotype is 2.37 (95% CI 1.04-5.41) and 1.75 (95% CI 1.24-2.56). The overall OR for the D allele in Asians also showed a similar magnitude, though without statistical significance (p = 0.09, p = 0.13, respectively). In Caucasians, both the DD genotype and D allele were associated with IgAN progression (OR 1.90, 1.61, respectively), but not IgAN susceptibility (p = 0.30, p = 0.41, respectively).
Our findings support the notion that ACE I/D polymorphism is associated with IgAN. Meanwhile, the role of ACE I/D polymorphism in Asians is different from that of Caucasians.
背景/目的：血管紧张素I转换酶（ACE）基因插入/缺失（I/D）多态性与免疫球蛋白A（IgA）肾病（IgAN）的相关性已得到广泛研究，但结果存在矛盾。我们进行了一项荟萃分析，以评估ACE I/D多态性与不同种族IgAN的相关性。
本分析使用了11项检测ACE I/D多态性与IgAN易感性之间关联的研究，以及9项检测ACE I/D与IgAN进展关联的研究。通过固定或随机效应模型估计总体比值比（OR）。
亚洲人中，DD基因型IgAN易感性和进展风险的总体OR分别为2.37（95%可信区间1.04 - 5.41）和1.75（95%可信区间1.24 - 2.56）。亚洲人中D等位基因的总体OR也显示出相似幅度，尽管无统计学意义（分别为p = 0.09，p = 0.13）。在白种人中，DD基因型和D等位基因均与IgAN进展相关（OR分别为1.90、1.61），但与IgAN易感性无关（分别为p = 0.30，p = 0.41）。
我们的研究结果支持ACE I/D多态性与IgAN相关的观点。同时，ACE I/D多态性在亚洲人和白种人中的作用不同。
