Zhou Tian-Biao, Qin Yuan-Han, Su Li-Na, Lei Feng-Ying, Huang Wei-Fang, Zhao Yan-Jun
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Int J Nephrol. 2011;2011:360357. doi: 10.4061/2011/360357. Epub 2011 May 9.
Aim. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and MCNS susceptibility. Method. A predefined literature search and selection of eligible relevant studies were performed to collect the data from electronic databases. Results. Six articles were identified for the analysis of association between ACE I/D gene polymorphism and MCNS risk, including 4 for Asians, one in Caucasian population and one for Africans. There was a markedly positive association between D allele or DD genotype and MCNS susceptibility in Asians (D: P = .01, DD: P = .02), but not for Caucasians and Africans (Caucasians: D: P = .16, DD: P = .98; Africans: D: P = .81, DD: P = .49). Furthermore, the II genotype seemed not to play a protective role against MCNS risk for Asians, Caucasians and Africans (P = .12, P = .09, P = .76, resp.). Interestingly, there was also significant association between ACE I/D gene polymorphism and MCNS susceptibility in overall populations (D: P = .007, DD: P = .04, II: P = .03). Conclusion. D allele or DD genotype might be a significant genetic molecular marker for MCNS susceptibility in Asians and overall populations, but not for Caucasians and Africans. More larger and rigorous genetic epidemiological investigations are required to further explore this association.
目的。进行此项荟萃分析以评估血管紧张素转换酶（ACE）I/D基因多态性与微小病变肾病（MCNS）易感性之间的关联。方法。进行预先定义的文献检索并筛选符合条件的相关研究，以从电子数据库中收集数据。结果。共确定6篇文章用于分析ACE I/D基因多态性与MCNS风险之间的关联，其中4篇针对亚洲人群，1篇针对高加索人群，1篇针对非洲人群。在亚洲人群中，D等位基因或DD基因型与MCNS易感性之间存在显著正相关（D：P = 0.01，DD：P = 0.02），但在高加索人和非洲人群中无此关联（高加索人：D：P = 0.16，DD：P = 0.98；非洲人：D：P = 0.81，DD：P = 0.49）。此外，对于亚洲人、高加索人和非洲人，II基因型似乎对MCNS风险不具有保护作用（分别为P = 0.12、P = 0.09、P = 0.76）。有趣的是，在总体人群中，ACE I/D基因多态性与MCNS易感性之间也存在显著关联（D：P = 0.007，DD：P = 0.04，II：P = 0.03）。结论。D等位基因或DD基因型可能是亚洲人群和总体人群中MCNS易感性的重要遗传分子标记，但在高加索人和非洲人群中并非如此。需要更多更大规模且严谨的遗传流行病学调查来进一步探究这种关联。
