SNARE蛋白与免疫：SNARE蛋白在免疫系统中的作用

SNAREing immunity: the role of SNAREs in the immune system.

作者信息

Stow Jennifer L, Manderson Anthony P, Murray Rachael Z

机构信息

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

出版信息

Nat Rev Immunol. 2006 Dec;6(12):919-29. doi: 10.1038/nri1980.

DOI:10.1038/nri1980

PMID:17124513

Abstract

The trafficking of molecules and membranes within cells is a prerequisite for all aspects of cellular immune functions, including the delivery and recycling of cell-surface proteins, secretion of immune mediators, ingestion of pathogens and activation of lymphocytes. SNARE (soluble-N-ethylmaleimide-sensitive-factor accessory-protein receptor)-family members mediate membrane fusion during all steps of trafficking, and function in almost all aspects of innate and adaptive immune responses. Here, we provide an overview of the roles of SNAREs in immune cells, offering insight into one level at which precision and tight regulation are instilled on immune responses.

摘要

细胞内分子和膜的运输是细胞免疫功能各个方面的先决条件，包括细胞表面蛋白的递送和循环利用、免疫介质的分泌、病原体的摄取以及淋巴细胞的激活。SNARE（可溶性N - 乙基马来酰亚胺敏感因子附着蛋白受体）家族成员在运输的所有步骤中介导膜融合，并在先天性和适应性免疫反应的几乎所有方面发挥作用。在这里，我们概述了SNARE在免疫细胞中的作用，深入了解了赋予免疫反应精确性和严格调控的一个层面。