Chaineau Mathilde, Danglot Lydia, Galli Thierry
Membrane Traffic in Neuronal and Epithelial Morphogenesis', INSERM U950, Paris F-75013, France.
FEBS Lett. 2009 Dec 3;583(23):3817-26. doi: 10.1016/j.febslet.2009.10.026. Epub 2009 Oct 20.
SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins are the core machinery of membrane fusion. Vesicular SNAREs (v-SNAREs) interact with their target SNAREs (t-SNAREs) to form SNARE complexes which mediate membrane fusion. Here we review the basic properties and functions of the v-SNARE TI-VAMP/VAMP7 (Tetanus neurotoxin insensitive-vesicle associated membrane protein). TI-VAMP interacts with its t-SNARE partners, particularly plasmalemmal syntaxins, to mediate membrane fusion and with several regulatory proteins especially via its amino-terminal regulatory Longin domain. Partners include AP-3, Hrb/(Human immunodeficiency virus Rev binding) protein, and Varp (Vps9 domain and ankyrin repeats containing protein) and regulate TI-VAMP's function and targeting. TI-VAMP is involved both in secretory and endocytic pathways which mediate neurite outgrowth and synaptic transmission, plasma membrane remodeling and lysosomal secretion.
SNARE（可溶性N - 乙基马来酰亚胺敏感因子附着蛋白受体）蛋白是膜融合的核心机制。囊泡SNARE（v - SNARE）与它们的靶标SNARE（t - SNARE）相互作用形成SNARE复合体，介导膜融合。在此，我们综述v - SNARE TI - VAMP/VAMP7（破伤风神经毒素不敏感的囊泡相关膜蛋白）的基本特性和功能。TI - VAMP与其t - SNARE伙伴相互作用，特别是质膜 syntaxins，以介导膜融合，并与几种调节蛋白相互作用，尤其是通过其氨基末端调节性的Longin结构域。伙伴包括AP - 3、Hrb/（人类免疫缺陷病毒Rev结合）蛋白和Varp（含Vps9结构域和锚蛋白重复序列的蛋白），并调节TI - VAMP的功能和靶向定位。TI - VAMP参与分泌和内吞途径，介导神经突生长和突触传递、质膜重塑以及溶酶体分泌。
