Hassanpour Parisa, Sadeghsoltani Fatemeh, Safari Mir-Meghdad, Haiaty Sanya, Rahbarghazi Reza, Mota Ali, Rahmati Mohamad
Department of Clinical Biochemistry and Laboratory Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Bioimpacts. 2024 Jul 2;15:30333. doi: 10.34172/bi.30333. eCollection 2025.
Adaptive inflammation consists of multiple cellular changes and molecular reactions to protect host cells against several pathological conditions. Along with the activation of varied immune cells, the production and secretion of cytokines arrays can regulate the progression of inflammatory response in a paracrine manner. Among different molecular cascades, Toll-like receptors (TLRs) are activated in response to several pathological conditions and damage signals. It has been indicated that extracellular vesicles, especially exosomes (Exos) are key bioshuttles with specific cargoes and are involved in cell-to-cell communication. The role of Exos in the initiation, progression, and cession of inflammation has been previously addressed in terms of cytokine transmission. Whether and how the activation of TLRs can alter the Exo biogenesis and angiogenesis potential in immune cells and endothelial cells (ECs) remains to be elucidated. Here, the cross-talk between the TLRs, Exo biogenesis, and angiogenesis has been highlighted.
适应性炎症由多种细胞变化和分子反应组成，以保护宿主细胞免受多种病理状况的影响。随着各种免疫细胞的激活，细胞因子阵列的产生和分泌可以旁分泌方式调节炎症反应的进程。在不同的分子级联反应中，Toll样受体（TLRs）会响应多种病理状况和损伤信号而被激活。已有研究表明，细胞外囊泡，尤其是外泌体（Exos）是携带特定货物的关键生物穿梭体，参与细胞间通讯。外泌体在炎症的起始、进展和终止中的作用此前已从细胞因子传递的角度进行了探讨。TLRs的激活是否以及如何改变免疫细胞和内皮细胞（ECs）中外泌体的生物发生和血管生成潜能仍有待阐明。在此，TLRs、外泌体生物发生和血管生成之间的相互作用已得到强调。
