Pedersen-Bjergaard U, Nielsen L B, Jensen K, Edvinsson L, Jansen I, Olesen J
Department of Neurology, Gentofte Hospital, University of Copenhagen, Denmark.
Peptides. 1991 Mar-Apr;12(2):333-7. doi: 10.1016/0196-9781(91)90022-h.
Calcitonin gene-related peptide (CGRP) was injected alone and in combination with substance P (SP) or neurokinin A (NKA) into the forearm skin and temporal muscle of human volunteers. In the skin, 50 pmol of CGRP induced a wheal response and a delayed erythema. No pain was recorded. No interaction between CGRP and SP or NKA was observed. In the temporal muscle, 200 pmol of CGRP alone did not induce pain or tenderness but, in combination with SP or NKA, CGRP elicited a significant pain sensation. It is concluded that CGRP may be involved in neurogenic inflammation and that only SP, of the three peptides present in nociceptive C fibers, seems to be of major importance in relation to cutaneous nociception. Simultaneous neurogenic release of CGRP and other neuropeptides in skeletal muscle may induce myofascial pain.
将降钙素基因相关肽（CGRP）单独以及与P物质（SP）或神经激肽A（NKA）联合注射到人类志愿者的前臂皮肤和颞肌中。在皮肤中，50皮摩尔的CGRP可诱发风团反应和迟发性红斑。未记录到疼痛。未观察到CGRP与SP或NKA之间存在相互作用。在颞肌中，单独使用200皮摩尔的CGRP不会诱发疼痛或压痛，但与SP或NKA联合使用时，CGRP会引发明显的疼痛感。得出的结论是，CGRP可能参与神经源性炎症，并且在伤害性C纤维中存在的三种肽中，只有SP似乎在皮肤伤害感受方面具有重要意义。骨骼肌中CGRP和其他神经肽的同时神经源性释放可能诱发肌筋膜疼痛。
