Wongkamchai S, Rochjanawatsiriroj C, Monkong N, Nochot H, Loymek S, Jiraamornnimit C, Hunnangkul S, Choochote W
Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok-Noi, Bangkok, Thailand.
J Helminthol. 2006 Dec;80(4):363-7. doi: 10.1017/joh2006365.
To study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern Thailand. The dominant isotype of antifilarial antibody was IgG4. A significantly higher percentage of individuals were positive for IgG1 in the microfilaraemic and lymphangitis groups compared with the elephantiasis and endemic normal patients, while a significantly higher positive rate of IgG3 was found in those with lymphangitis. The possible role of these isotypes for diagnostic purposes and the pattern of antibody response in various clinically manifesting groups are discussed.
为研究抗丝虫IgG亚类在马来布鲁线虫病临床谱中的诊断意义，我们对居住在泰国南部那拉提瓦省的74名无症状无微丝蚴血症者、30名微丝蚴血症者、20名淋巴管炎患者和16名象皮肿患者组成的暴露人群进行了IgG1、IgG3和IgG4抗丝虫抗体检测。该地区是马来布鲁线虫淋巴丝虫病的流行区。抗丝虫抗体的主要亚型为IgG4。与象皮肿患者和地方性正常人群相比，微丝蚴血症组和淋巴管炎组中IgG1阳性个体的比例显著更高，而淋巴管炎患者中IgG3的阳性率显著更高。本文讨论了这些亚型在诊断中的可能作用以及不同临床表现组的抗体反应模式。
