单纯疱疹病毒1型（HSV-1）的DNA疫苗编码糖蛋白B无法保护经慢性吗啡处理的小鼠免受HSV-1攻击。
DNA vaccine-encoded glycoprotein B of HSV-1 fails to protect chronic morphine-treated mice against HSV-1 challenge.
作者信息
Jamali Abbas, Roostaee Mohammad H, Soleimanjahi Hoorieh, Ghaderi Pakdel Firouz, Bamdad Taravat
机构信息
Department of Virology, School of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-111, Tehran, Iran.
出版信息
Comp Immunol Microbiol Infect Dis. 2007 Mar;30(2):71-80. doi: 10.1016/j.cimid.2006.10.002. Epub 2006 Nov 28.
The use of morphine has been demonstrated to increase susceptibility to infections. Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen among immunocompromised individuals. In the present study, due to the importance of HSV vaccination in morphine abusers, the effects of chronic morphine exposure on the host response to a HSV-1 gB DNA-based vaccine have been investigated. The study is addressing an important aspect of vaccine development among the susceptible (immunocompromised) hosts. BALB/c mice were exposed to morphine over 11 days. They were then vaccinated with DNA vaccine or KOS strain as a live vaccine. The findings showed that the morphine-treated animals failed to respond to DNA vaccination evaluated by the anti-HSV gB antibody titer, delayed type hypersensitivity (DTH) and lethal HSV-1 challenge. Under the same conditions, the KOS vaccine showed a reduced Ab titer and DTH response in morphine-treated mice, but could protect mice against the lethal challenge and was safe for vaccination of morphine-treated animals.
已证明使用吗啡会增加感染易感性。单纯疱疹病毒1型（HSV-1）在免疫功能低下个体中是一种非常成功的病原体。在本研究中，鉴于HSV疫苗接种对吗啡滥用者的重要性，研究了慢性吗啡暴露对宿主对基于HSV-1 gB DNA疫苗反应的影响。该研究正在解决易感（免疫功能低下）宿主中疫苗开发的一个重要方面。BALB/c小鼠在11天内接触吗啡。然后用DNA疫苗或作为活疫苗的KOS株进行接种。研究结果表明，通过抗HSV gB抗体滴度、迟发型超敏反应（DTH）和致死性HSV-1攻击评估，经吗啡处理的动物对DNA疫苗接种无反应。在相同条件下，KOS疫苗在经吗啡处理的小鼠中显示出抗体滴度降低和DTH反应减弱，但可以保护小鼠免受致死性攻击，并且对经吗啡处理的动物进行疫苗接种是安全的。
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