一种在原发性或转移性肿瘤中区分下消化道粘蛋白与其他粘蛋白的组织化学方法。
A histochemical method of differentiating lower gastrointestinal tract mucin from other mucins in primary or metastatic tumours.
作者信息
Culling C F, Reid P E, Burton J D, Dunn W L
出版信息
J Clin Pathol. 1975 Aug;28(8):656-8. doi: 10.1136/jcp.28.8.656.
Abstract
Epithelial mucins of the normal terminal ileum, caecum, colon, and rectum of man are unique in that they alone exhibit staining following the periodate-borohydride/KOH/PAS technique. Application of this technique enables one to differentiate those mucin-producting metastases arising from adenocarcinoma of the lower gastrointestinal tract from those arising elsewhere, and may occasionally be useful in determining the site of the primary tumour when it is in doubt. Furthermore, it was found to be especially useful in distinguishing between primary adenocarcinoma of the lung and metastases in the lung from adenocarcinoma of the lower gastrointestinal tract.
摘要
人类正常回肠末端、盲肠、结肠和直肠的上皮粘蛋白具有独特之处，即只有它们在用高碘酸盐-硼氢化物/KOH/过碘酸希夫氏反应（PAS）技术处理后会出现染色。应用该技术能够区分下消化道腺癌产生的粘蛋白生成性转移灶与其他部位产生的转移灶，并且在原发性肿瘤部位存疑时，偶尔有助于确定原发性肿瘤的位置。此外，还发现该技术在区分原发性肺腺癌与下消化道腺癌的肺转移方面特别有用。
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本文引用的文献
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Saponification-induced increase in the periodic acid-Schiff reaction in the gastrointestinal tract. Mechanism and distribution of the reactive substance.
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The effect of saponification upon certain histochemical reactions of the epithelial mucins of the gastrointestinal tract.皂化作用对胃肠道上皮粘蛋白某些组织化学反应的影响。
J Histochem Cytochem. 1971 Nov;19(11):654-62. doi: 10.1177/19.11.654.
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The demonstration of O-acetylated sialic acids in colonic epithelial glycoproteins.
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