Giménez M, Junqué C, Vendrell P, Narberhaus A, Bargalló N, Botet F, Mercader J M
Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, Spain.
Neurology. 2006 Nov 28;67(10):1818-22. doi: 10.1212/01.wnl.0000244485.51898.93.
To investigate the effects of prematurity on sulcal formation.
We evaluated the depth and volume of the primary olfactory sulcus (developed at 16 weeks' gestation) and the secondary orbital sulci (which start to develop at 28 weeks' gestation) in a sample of 22 adolescents with history of very-preterm birth (VPTB). We compared this preterm sample with a sample of subjects born at term and matched by age, gender, and sociocultural status. The Anatomist/BrainVISA 3.0.1 package was used to identify and quantify the sulci. In addition, voxel-based morphometry (VBM) was used to analyze possible reductions of gray and white matter in the orbitofrontal area.
Compared with controls, we found a significant reduction in the secondary sulci depth but not in the primary sulcus in the VPTB. VBM analysis showed reduced gray-matter volume in VPTB in the orbital region.
Premature birth affects cerebral gyrification, and this impairment is not reversible during childhood. Identification of the specific factors involved in abnormal brain maturation may lead to effective interventions.
研究早产对脑沟形成的影响。
我们评估了22名有极早产史（VPTB）青少年样本中初级嗅沟（在妊娠16周时发育）和次级眶沟（在妊娠28周时开始发育）的深度和体积。我们将这个早产样本与一组足月出生、年龄、性别和社会文化地位相匹配的受试者样本进行比较。使用Anatomist/BrainVISA 3.0.1软件包来识别和量化脑沟。此外，基于体素的形态学测量（VBM）用于分析眶额叶区域灰质和白质可能的减少情况。
与对照组相比，我们发现VPTB组中次级脑沟深度显著降低，但初级脑沟深度未降低。VBM分析显示VPTB组眶区灰质体积减少。
早产会影响脑回形成，且这种损害在儿童期不可逆转。确定参与异常脑成熟的具体因素可能会带来有效的干预措施。
