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用于治疗病态肥胖的胃束带术会减轻还是加重胃食管反流?

Does gastric banding for morbid obesity reduce or increase gastroesophageal reflux?

作者信息

Tolonen Pekka, Victorzon Mikael, Niemi Risto, Mäkelä Jyrki

机构信息

Department of Gastrointestinal Surgery, Vasa Central Hospital, Vasa, Finland.

出版信息

Obes Surg. 2006 Nov;16(11):1469-74. doi: 10.1381/096089206778870120.

Abstract

BACKGROUND

Conflicting results regarding the influence of laparoscopic adjustable gastric banding (LAGB) on gastroesophageal reflux disease (GERD) have been published.

METHODS

A prospective follow-up study was conducted in 31 patients (male/female 5/26, mean age 44 +/- 11 SD years) with 24-hour pH and manometry recordings, symptom assessment, and upper GI endoscopy.

RESULTS

Total number of reflux episodes decreased from a mean value of 44.6 +/- 23.7 SD preoperatively to 22.9 +/- 17.1 postoperatively (P=0.0006), after a median follow-up time of 19 months (range 7-32 months). Total reflux time decreased from 9.5% +/- 6.2% to 3.5% +/- 3.7%, P=0.0009, and DeMeester score decreased from 38.5 +/- 24.9 to 18.6 +/- 20.4, P=0.03. Symptomatic patients decreased from 48.4% preoperatively to 16.1% postoperatively (P=0.01), medication for GERD decreased from 35.5% to 12.9% (P=0.05), and the diagnosis of GERD on 24-hour pH recordings decreased from 77.4% to 37.5% (P=0.01). There were no pouch enlargements seen on upper GI endoscopy. Esophageal motility was unchanged, but 36% of the patients had incomplete relaxation of the lower esophageal sphincter following the operation (P<0.0001). Mean BMI decreased from 46.0 +/- 5.46 to 38.4 +/- 6.45 (P<0.0001), excess weight from 60.0 kg +/- 18.58 kg, 44.9% +/- 6.56% to 38.4 kg +/- 20.27 kg, 28.4% +/- 10.97% (P<0.0001). No association between the postoperative diagnosis of GERD and the amount of weight loss could be found.

CONCLUSIONS

The correctly placed gastric band is an effective anti-reflux barrier in the short term. Long-term results have to be awaited.

摘要

背景

关于腹腔镜可调节胃束带术(LAGB)对胃食管反流病(GERD)影响的研究结果存在冲突。

方法

对31例患者(男5例/女26例,平均年龄44±11标准差岁)进行前瞻性随访研究,记录24小时pH值和测压情况,评估症状,并进行上消化道内镜检查。

结果

在中位随访时间19个月(范围7 - 32个月)后,反流发作总数从术前的平均值44.6±23.7标准差降至术后的22.9±17.1(P = 0.0006)。总反流时间从9.5%±6.2%降至3.5%±3.7%,P = 0.0009,DeMeester评分从38.5±24.9降至18.6±20.4,P = 0.03。有症状的患者从术前的48.4%降至术后的16.1%(P = 0.01),用于GERD的药物从35.5%降至12.9%(P = 0.05),24小时pH记录诊断为GERD的比例从77.4%降至37.5%(P = 0.01)。上消化道内镜检查未见胃囊扩大。食管动力未改变,但36%的患者术后食管下括约肌松弛不完全(P < 0.0001)。平均体重指数从46.0±5.46降至38.4±6.45(P < 0.0001),超重从60.0 kg±18.58 kg,44.9%±6.56%降至38.4 kg±20.27 kg,28.4%±10.97%(P < 0.0001)。未发现术后GERD诊断与体重减轻量之间存在关联。

结论

正确放置的胃束带在短期内是有效的抗反流屏障。长期结果有待观察。

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