Tolonen Pekka, Victorzon Mikael, Niemi Risto, Mäkelä Jyrki
Department of Gastrointestinal Surgery, Vasa Central Hospital, Vasa, Finland.
Obes Surg. 2006 Nov;16(11):1469-74. doi: 10.1381/096089206778870120.
Conflicting results regarding the influence of laparoscopic adjustable gastric banding (LAGB) on gastroesophageal reflux disease (GERD) have been published.
A prospective follow-up study was conducted in 31 patients (male/female 5/26, mean age 44 +/- 11 SD years) with 24-hour pH and manometry recordings, symptom assessment, and upper GI endoscopy.
Total number of reflux episodes decreased from a mean value of 44.6 +/- 23.7 SD preoperatively to 22.9 +/- 17.1 postoperatively (P=0.0006), after a median follow-up time of 19 months (range 7-32 months). Total reflux time decreased from 9.5% +/- 6.2% to 3.5% +/- 3.7%, P=0.0009, and DeMeester score decreased from 38.5 +/- 24.9 to 18.6 +/- 20.4, P=0.03. Symptomatic patients decreased from 48.4% preoperatively to 16.1% postoperatively (P=0.01), medication for GERD decreased from 35.5% to 12.9% (P=0.05), and the diagnosis of GERD on 24-hour pH recordings decreased from 77.4% to 37.5% (P=0.01). There were no pouch enlargements seen on upper GI endoscopy. Esophageal motility was unchanged, but 36% of the patients had incomplete relaxation of the lower esophageal sphincter following the operation (P<0.0001). Mean BMI decreased from 46.0 +/- 5.46 to 38.4 +/- 6.45 (P<0.0001), excess weight from 60.0 kg +/- 18.58 kg, 44.9% +/- 6.56% to 38.4 kg +/- 20.27 kg, 28.4% +/- 10.97% (P<0.0001). No association between the postoperative diagnosis of GERD and the amount of weight loss could be found.
The correctly placed gastric band is an effective anti-reflux barrier in the short term. Long-term results have to be awaited.
关于腹腔镜可调节胃束带术(LAGB)对胃食管反流病(GERD)影响的研究结果存在冲突。
对31例患者(男5例/女26例,平均年龄44±11标准差岁)进行前瞻性随访研究,记录24小时pH值和测压情况,评估症状,并进行上消化道内镜检查。
在中位随访时间19个月(范围7 - 32个月)后,反流发作总数从术前的平均值44.6±23.7标准差降至术后的22.9±17.1(P = 0.0006)。总反流时间从9.5%±6.2%降至3.5%±3.7%,P = 0.0009,DeMeester评分从38.5±24.9降至18.6±20.4,P = 0.03。有症状的患者从术前的48.4%降至术后的16.1%(P = 0.01),用于GERD的药物从35.5%降至12.9%(P = 0.05),24小时pH记录诊断为GERD的比例从77.4%降至37.5%(P = 0.01)。上消化道内镜检查未见胃囊扩大。食管动力未改变,但36%的患者术后食管下括约肌松弛不完全(P < 0.0001)。平均体重指数从46.0±5.46降至38.4±6.45(P < 0.0001),超重从60.0 kg±18.58 kg,44.9%±6.56%降至38.4 kg±20.27 kg,28.4%±10.97%(P < 0.0001)。未发现术后GERD诊断与体重减轻量之间存在关联。
正确放置的胃束带在短期内是有效的抗反流屏障。长期结果有待观察。