幽门螺杆菌对碳水化合物的黏附作用。
Helicobacter pylori adhesion to carbohydrates.
作者信息
Aspholm Marina, Kalia Awdhesh, Ruhl Stefan, Schedin Staffan, Arnqvist Anna, Lindén Sara, Sjöström Rolf, Gerhard Markus, Semino-Mora Cristina, Dubois Andre, Unemo Magnus, Danielsson Dan, Teneberg Susann, Lee Woo-Kon, Berg Douglas E, Borén Thomas
机构信息
Department of Molecular Biosciences, University of Oslo, Oslo, Norway.
出版信息
Methods Enzymol. 2006;417:293-339. doi: 10.1016/S0076-6879(06)17020-2.
Abstract
Adherence of bacterial pathogens to host tissues contributes to colonization and virulence and typically involves specific interactions between bacterial proteins called adhesins and cognate oligosaccharide (glycan) or protein motifs in the host that are used as receptors. A given pathogen may have multiple adhesins, each specific for a different set of receptors and, potentially, with different roles in infection and disease. This chapter provides strategies for identifying and analyzing host glycan receptors and the bacterial adhesins that exploit them as receptors, with particular reference to adherence of the gastric pathogen Helicobacter pylori.
摘要
细菌病原体对宿主组织的黏附有助于其定植和致病，通常涉及被称为黏附素的细菌蛋白与宿主中用作受体的同源寡糖（聚糖）或蛋白基序之间的特异性相互作用。特定的病原体可能有多种黏附素，每种黏附素对不同的受体具有特异性，并且在感染和疾病中可能具有不同的作用。本章提供了识别和分析宿主聚糖受体以及将这些受体作为靶点的细菌黏附素的策略，特别提及了胃病原体幽门螺杆菌的黏附。
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