Department of Microbiology, Chitwan Medical College and Teaching Hospital, Bharatpur 44200, Chitwan, Nepal.
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan.
Toxins (Basel). 2019 Nov 19;11(11):677. doi: 10.3390/toxins11110677.
colonizes the gastric epithelial cells of at least half of the world's population, and it is the strongest risk factor for developing gastric complications like chronic gastritis, ulcer diseases, and gastric cancer. To successfully colonize and establish a persistent infection, the bacteria must overcome harsh gastric conditions. has a well-developed mechanism by which it can survive in a very acidic niche. Despite bacterial factors, gastric environmental factors and host genetic constituents together play a co-operative role for gastric pathogenicity. The virulence factors include bacterial colonization factors BabA, SabA, OipA, and HopQ, and the virulence factors necessary for gastric pathogenicity include the effector proteins like CagA, VacA, HtrA, and the outer membrane vesicles. Bacterial factors are considered more important. Here, we summarize the recent information to better understand several bacterial virulence factors and their role in the pathogenic mechanism.
定植于全世界至少一半人口的胃上皮细胞，是导致慢性胃炎、溃疡病和胃癌等胃并发症的最强危险因素。为了成功定植和建立持续感染，细菌必须克服恶劣的胃环境。具有一种使其能够在非常酸性小生境中生存的发达机制。尽管存在细菌因素，但胃环境因素和宿主遗传成分共同发挥协同作用，导致胃致病性。毒力因子包括细菌定植因子 BabA、SabA、OipA 和 HopQ，以及与胃致病性相关的必需毒力因子，如效应蛋白 CagA、VacA、HtrA 和外膜囊泡。细菌因素被认为更为重要。在这里，我们总结了最近的信息，以更好地了解几种细菌毒力因子及其在致病机制中的作用。
