Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Department of Biomedical, Indian Scientific Education and Technology Foundation, Lucknow 221005, India.
Curr Pharm Des. 2024;30(32):2505-2512. doi: 10.2174/0113816128296168240614071821.
Diabetes mellitus is a metabolic disorder characterized by high blood sugar levels. In recent years, T2DM has become a worldwide health issue due to an increase in incidence and prevalence. Diabetic kidney disease (DKD) is one of the devastating consequences of diabetes, especially owing to T2DM and the key clinical manifestation of DKD is weakened renal function and progressive proteinuria. DKD affects approximately 1/3rd of patients with diabetes mellitus, and T2DM is the predominant cause of end-stage kidney disease (ESKD). Several lines of studies have observed the association between vitamin D deficiency and the progression and etiology of type II diabetes mellitus. Emerging experimental evidence has shown that T2DM is associated with various kinds of kidney diseases. Recent evidence has also shown that an alteration in VDR (vitamin D receptor) signaling in podocytes leads to DKD. The present review aims to examine vitamin D metabolism and its correlation with T2DM. Furthermore, we discuss the potential role of vitamin D and VDR in diabetic kidney disease.
糖尿病是一种代谢紊乱疾病，其特征是血糖水平升高。近年来，由于发病率和患病率的增加，T2DM 已成为全球健康问题。糖尿病肾病（DKD）是糖尿病的毁灭性后果之一，特别是由于 T2DM，DKD 的主要临床症状是肾功能减弱和进行性蛋白尿。大约有 1/3 的糖尿病患者患有 DKD，而 T2DM 是终末期肾病（ESKD）的主要原因。一些研究观察到维生素 D 缺乏与 2 型糖尿病的进展和病因之间的关联。新出现的实验证据表明，T2DM 与各种肾脏疾病有关。最近的证据还表明，足细胞中 VDR（维生素 D 受体）信号的改变导致 DKD。本综述旨在探讨维生素 D 代谢及其与 T2DM 的相关性。此外，我们还讨论了维生素 D 和 VDR 在糖尿病肾病中的潜在作用。
