Manurung Daulat
Division of Cardiology, Department of Internal Medicine Faculty of Medicine, University of Indonesia-dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Acta Med Indones. 2006 Oct-Dec;38(4):196-201.
to see which component of the triad lipid that has more important role and frequently found in patients with acute coronary syndrome, focusing on HDL cholesterol.
a lipid profile study has been conducted in 391 patients with acute coronary syndrome (ACS), who have been hospitalized in ICCU of Cipto Mangunkusumo Hospital since January 1st, 2001 - December 31st, 2005.
there were 294 male patients (75.2%) and 97 female patients (24.8%), from 25-89 years age group, with mean value 57.35 +/- 11.05. The mean value of total cholesterol level was 205.23 mg/dl +/- 54.84. The LDL cholesterol level was 136.16 mg/dl +/- 47.29. The mean HDL cholesterol level was 42.84 mg/dl +/- 10.28, mean triglycerides level was 157.25 mg/dl +/- 100.16. There were 82 patients (21%) with high total cholesterol (> 240 mg/dl), 102 patients (26.1%) with high and very high LDL cholesterol level (> 160 mg/dl), 152 (38.6%) patients with low HDL cholesterol level (< 40 mg/dl), consisted of 126 male patients or 42.9% of total male patients, 26 female patients or 26.8% of total female patients. The number of patients with high / very high triglycerides level (> 200 mg/dl or 500 mg/dl) was 84 patients (21.5%). The number of patients with optimal lipid level, total cholesterol level < 200 mg/dl was 191 patients (48.8%); 82 patients (21%) had LDL cholesterol level < 100 mg/dl, 23 patients (5.9%) had HDL cholesterol level > 60 mg/dl, 226 patients (57.8%) had triglycerides level < 150 mg/dl. There were 260 patients with atherogenic lipid profile (64%), 135 patients with borderline lipid profile (34.5%), and optimal lipid profile was found only in 6 patients (1,5%). The mean value of HDL cholesterol level in male patients was 41.75 mg/dl +/- 9.9, while HDL cholesterol level in female patients was 46.16 mg/dl +/- 10.74. Principally, lipid profiles of all age groups were evenly distributed. ACS patients with history of family heart disease had a more atherogenic lipid profile compared to lipid profile of patients with hypertension, diabetes mellitus, and cigarette smoking.
atherogenic lipid profile is more common risk factor in ACS patients than in other non-lipid risk factors. This study also demonstrated that the atherogenic lipid is most commonly found in patient with low HDL cholesterol level and it is least frequently found in patient with optimal lipid profile.
研究三联脂质成分中哪个在急性冠脉综合征患者中作用更重要且更常见，重点关注高密度脂蛋白胆固醇。
对391例急性冠脉综合征（ACS）患者进行了血脂谱研究，这些患者于2001年1月1日至2005年12月31日期间在西爪哇省茂物市芝多曼古苏莫医院的冠心病重症监护病房住院。
有294例男性患者（75.2%）和97例女性患者（24.8%），年龄在25 - 89岁之间，平均值为57.35 +/- 11.05。总胆固醇水平平均值为205.23毫克/分升 +/- 54.84。低密度脂蛋白胆固醇水平为136.16毫克/分升 +/- 47.29。高密度脂蛋白胆固醇水平平均值为42.84毫克/分升 +/- 10.28，甘油三酯水平平均值为157.25毫克/分升 +/- 100.16。82例患者（21%）总胆固醇高（> 240毫克/分升），102例患者（26.1%）低密度脂蛋白胆固醇水平高或极高（> 160毫克/分升），152例（38.6%）患者高密度脂蛋白胆固醇水平低（< 40毫克/分升），其中男性患者126例，占男性患者总数的42.9%，女性患者26例，占女性患者总数的26.8%。高/极高甘油三酯水平（> 200毫克/分升或500毫克/分升）的患者有84例（21.5%）。血脂水平最佳的患者，总胆固醇水平 < 200毫克/分升的有191例（48.8%）；低密度脂蛋白胆固醇水平 < 100毫克/分升的有82例（21%），高密度脂蛋白胆固醇水平 > 60毫克/分升的有23例（5.9%），甘油三酯水平 < 150毫克/分升的有226例（57.8%）。有260例患者具有致动脉粥样硬化血脂谱（64%），135例患者血脂谱临界（34.5%），仅6例患者（1.5%）血脂谱最佳。男性患者高密度脂蛋白胆固醇水平平均值为41.75毫克/分升 +/- 9.9，而女性患者高密度脂蛋白胆固醇水平为46.16毫克/分升 +/- 10.74。总体而言，各年龄组的血脂谱分布均匀。有家族心脏病史的ACS患者的血脂谱比有高血压、糖尿病和吸烟史的患者更具致动脉粥样硬化性。
致动脉粥样硬化血脂谱在ACS患者中比其他非脂质危险因素更常见。这项研究还表明，致动脉粥样硬化脂质最常见于高密度脂蛋白胆固醇水平低的患者，而在血脂谱最佳的患者中最少见。
