Markus P M, Cai X, Ming W, Demetris A J, Fung J J, Starzl T E
Department of Surgery, University of Pittsburgh School of Medicine, Pa.
Surgery. 1991 Aug;110(2):357-63; discussion 363-4.
Severe graft-versus-host disease was induced by transplantation of ACI rat bone marrow and spleen cells into irradiated Lewis rat recipients. Treatment with FK 506 or cyclosporine A (CsA) was started after clinical and histologic evidence of acute GVHD was present. A 14-day course of FK 506 at 1.0 mg/kg/day could rescue 100% of the animals suffering from GVHD. In contrast only one half of the animals treated with CsA at a high dose of 25 mg/kg/day recovered. After cessation of immunosuppressive therapy, FK 506-treated animals displayed a marked prolonged disease-free interval as compared to CsA-treated bone marrow recipients. Recurrence of the disease in these animals could be prevented when FK 506 treatment was continued after the induction period with a low maintenance dose of 0.1 mg/kg/day every other day.
将ACI大鼠的骨髓和脾细胞移植到经辐照的Lewis大鼠受体中，可诱发严重的移植物抗宿主病。在出现急性移植物抗宿主病的临床和组织学证据后，开始用FK 506或环孢素A（CsA）进行治疗。以1.0毫克/千克/天的剂量给予FK 506，疗程为14天，可使100%患有移植物抗宿主病的动物获救。相比之下，以25毫克/千克/天的高剂量给予CsA治疗的动物中，只有一半恢复。与接受CsA治疗的骨髓受体相比，停止免疫抑制治疗后，接受FK 506治疗的动物显示出明显延长的无病间隔期。在诱导期后，以0.1毫克/千克/天的低维持剂量隔日继续给予FK 506治疗，可预防这些动物疾病的复发。
