Yang Young-Keun, Tae Jinsung
Department of Chemistry and Center for Bioactive Molecular Hybrids (CBMH), Yonsei University, Seoul 120-749, Korea.
Org Lett. 2006 Dec 7;8(25):5721-3. doi: 10.1021/ol062323r.
A new, selective chemosensor has been developed to detect cyanide in water at micromolar concentrations. The acridinium salt used in this sensor system is prepared in a single step from an acridine orange base. Detection is based on the irreversible, 1:1 stoichiometric, nucleophilic addition of cyanide to the 9-position of the acridinium ion. This process induces a large decrease in fluorescence intensity and a marked color change. The selectivity of the system in aqueous media for CN- over other anions is remarkably high. Also, the sensitivity of both the fluorescence- and colorimetric-based assay is below the 1.9 microM suggested by the World Health Organization (WHO) as the maximum allowable cyanide concentration in drinking water. Thus, the chemodosimeter should be applicable as a practical system for the monitoring of CN- concentrations in aqueous samples. [structure: see text]
一种新型的选择性化学传感器已被开发出来，用于检测微摩尔浓度水中的氰化物。该传感器系统中使用的吖啶鎓盐由吖啶橙碱一步制备而成。检测基于氰化物与吖啶鎓离子9位的不可逆、1:1化学计量的亲核加成反应。这一过程会导致荧光强度大幅降低以及明显的颜色变化。该系统在水性介质中对CN-相对于其他阴离子的选择性非常高。此外，基于荧光和比色法的检测灵敏度均低于世界卫生组织（WHO）建议的饮用水中氰化物最大允许浓度1.9 microM。因此，这种化学计量器应可作为一种实用系统，用于监测水性样品中的CN-浓度。[结构：见正文]
