Torvaldsen Siranda, Roberts Christine L, Simpson Judy M, Thompson Jane F, Ellwood David A
NSW Centre for Overweight and Obesity, Level 2, K25 Medical Foundation Building, The University of Sydney, NSW 2006, Australia.
Int Breastfeed J. 2006 Dec 11;1:24. doi: 10.1186/1746-4358-1-24.
Anecdotal reports suggest that the addition of fentanyl (an opioid) to epidural analgesia for women during childbirth results in difficulty establishing breastfeeding. The aim of this paper is to determine any association between epidural analgesia and 1) breastfeeding in the first week postpartum and 2) breastfeeding cessation during the first 24 weeks postpartum.
A prospective cohort study of 1280 women aged > or = 16 years, who gave birth to a single live infant in the Australian Capital Territory in 1997 was conducted. Women completed questionnaires at weeks 1, 8, 16 and 24 postpartum. Breastfeeding information was collected in each of the four surveys and women were categorised as either fully breastfeeding, partially breastfeeding or not breastfeeding at all. Women who had stopped breastfeeding since the previous survey were asked when they stopped.
In the first week postpartum, 93% of women were either fully or partially breastfeeding their baby and 60% were continuing to breastfeed at 24 weeks. Intrapartum analgesia and type of birth were associated with partial breastfeeding and breastfeeding difficulties in the first postpartum week (p < 0.0001). Analgesia, maternal age and education were associated with breastfeeding cessation in the first 24 weeks (p < 0.0001), with women who had epidurals being more likely to stop breastfeeding than women who used non-pharmacological methods of pain relief (adjusted hazard ratio 2.02, 95% CI 1.53, 2.67).
Women in this cohort who had epidurals were less likely to fully breastfeed their infant in the few days after birth and more likely to stop breastfeeding in the first 24 weeks. Although this relationship may not be causal, it is important that women at higher risk of breastfeeding cessation are provided with adequate breastfeeding assistance and support.
轶事报道表明,分娩期间给女性硬膜外镇痛添加芬太尼(一种阿片类药物)会导致难以建立母乳喂养。本文的目的是确定硬膜外镇痛与1)产后第一周的母乳喂养以及2)产后前24周内停止母乳喂养之间是否存在关联。
对1997年在澳大利亚首都地区分娩单活婴的1280名年龄≥16岁的女性进行了一项前瞻性队列研究。女性在产后第1、8、16和24周完成问卷调查。在这四项调查中均收集了母乳喂养信息,女性被分类为完全母乳喂养、部分母乳喂养或根本不母乳喂养。对于自上次调查以来已停止母乳喂养的女性,询问她们何时停止。
产后第一周,93%的女性对其婴儿进行完全或部分母乳喂养,60%的女性在24周时仍在继续母乳喂养。产时镇痛和分娩方式与产后第一周的部分母乳喂养和母乳喂养困难相关(p<0.0001)。镇痛、产妇年龄和教育程度与前24周内停止母乳喂养相关(p<0.0001),接受硬膜外镇痛的女性比使用非药物镇痛方法的女性更有可能停止母乳喂养(调整后的风险比为2.02,95%置信区间为1.53,2.67)。
该队列中接受硬膜外镇痛的女性在出生后几天内完全母乳喂养婴儿的可能性较小,在前24周内停止母乳喂养的可能性较大。尽管这种关系可能不是因果关系,但为有较高停止母乳喂养风险的女性提供充分的母乳喂养援助和支持很重要。