Yousefshahi Fardin, Davari-Tanha Fatemeh, Najafi Atabak, Kaveh Mahbod, Rezaei Hemami Mohsen, Khashayar Patricia, Anbarafshan Mohammad
Department of Anesthesiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Family Reprod Health. 2016 Dec;10(4):176-183.
To assess the association between intrapartum intrathecal opioid use and breastfeeding and weight gain following cesarean section. The prospective double-blinded study was conducted on term pregnant women, undergoing elective cesarean section under spinal anesthesia. They divided into two groups. In the first group, intrathecal Morphine was used to achieve analgesia during or after the operation. The remainder divided into two subgroups, those who did not receive any opioid or those received systemic opioids. Following labor breastfeeding accessed in a follow-up, two month latter. There was no difference between the demographic variables of the mothers and newborns APGAR score and weight at the time of birth. Breastfeeding rate was similar in intrathecal group in compare with other patents (P value = 0.518). While, the infants' weight at the end of second month was lower in spinal opioid group (P value = 0.036). The present study was the first to suggest that spinal (intrathecal) opioids do not have any impact on breastfeeding. However the relationship between spinal anesthesia on weight gaining needs more investigation.
评估剖宫产术中鞘内使用阿片类药物与术后母乳喂养及体重增加之间的关联。这项前瞻性双盲研究针对足月孕妇开展,这些孕妇在腰麻下行择期剖宫产术。她们被分为两组。第一组在手术期间或术后使用鞘内吗啡以实现镇痛。其余孕妇分为两个亚组,一组未接受任何阿片类药物,另一组接受全身性阿片类药物。分娩后在两个月后的随访中评估母乳喂养情况。母亲的人口统计学变量、新生儿阿氏评分及出生时体重之间无差异。鞘内用药组的母乳喂养率与其他组相似(P值 = 0.518)。然而,鞘内使用阿片类药物组婴儿在第二个月末的体重较低(P值 = 0.036)。本研究首次表明,脊髓(鞘内)阿片类药物对母乳喂养没有任何影响。然而,腰麻与体重增加之间的关系需要更多研究。