用单纤维肌电图研究箭毒对降低人类运动终板安全因子的作用。
Regional curare for the reduction of the safety factor in human motor end-plates studied with single fibre electromyography.
作者信息
Schiller H H, Stålberg E, Schwartz M S
出版信息
J Neurol Neurosurg Psychiatry. 1975 Aug;38(8):805-9. doi: 10.1136/jnnp.38.8.805.
Abstract
A method employing six minutes of regional curarization with 0.5 mg D-tubocurarine and single fibre electromyographic measurements (SFEMG) was used in order to study the effect of an additional small dose of D-tubocurarine. The effect of the additional dose was most pronounced in terms of increased jitter, on motor end-plates with the initially highest jitter. The combination of regional curarization and SFEMG jitter recordings offers a sensitive technique for detecting mild effects of various drugs on neuromuscular transmission not detectable with decrement investigations.
摘要
为了研究额外小剂量筒箭毒碱的作用，采用了一种方法，即使用0.5毫克D-筒箭毒碱进行6分钟的局部肌松，并进行单纤维肌电图测量（SFEMG）。额外剂量的作用在最初抖动最高的运动终板上，以增加抖动最为明显。局部肌松和SFEMG抖动记录相结合，提供了一种灵敏的技术，用于检测各种药物对神经肌肉传递的轻微作用，而这些作用通过衰减研究无法检测到。
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