Krivoĭ I I, Seĭ T P
Fiziol Zh SSSR Im I M Sechenova. 1988 Dec;74(12):1751-8.
The acetylcholinesterase phospho-organic inhibitor armine (4.10(-7) M) reduces the muscle response to a single nerve stimulus (up to 50%) and the nerve-induced tetanic tension in the rat phrenic-diaphragm muscle preparation. Tubocurarine exerts a similar effect. Substitution of armine by 0.5.10(-7) or 1.10(-7) M tubocurarine for 60-90 min leads to almost complete restoration of neuromuscular transmission. In the presence of armine, tubocurarine exerts a considerably lesser effect. Possible pre- and post-synaptic mechanisms of the tubocurarine action, are discussed.
乙酰胆碱酯酶有机磷抑制剂阿米宁（4×10⁻⁷ M）可降低大鼠膈-膈肌标本中肌肉对单次神经刺激的反应（高达50%）以及神经诱导的强直张力。筒箭毒碱也有类似作用。用0.5×10⁻⁷或1×10⁻⁷ M筒箭毒碱替代阿米宁60 - 90分钟可使神经肌肉传递几乎完全恢复。在有阿米宁存在的情况下，筒箭毒碱的作用明显减弱。文中讨论了筒箭毒碱作用可能的突触前和突触后机制。
